Development of novel lithocholic acid derivatives as vitamin D receptor agonists.

Cell Differentiation Cholecalciferol / analogs & derivatives Humans Lithocholic Acid / pharmacology
Cell differentiation Lithocholic acid Nuclear receptor Vitamin D

Journal

Bioorganic & medicinal chemistry
ISSN: 1464-3391
Titre abrégé: Bioorg Med Chem
Pays: England
ID NLM: 9413298

Informations de publication

Date de publication:
15 08 2019
Historique:
received: 04 06 2019
revised: 01 07 2019
accepted: 03 07 2019
pubmed: 14 7 2019
medline: 17 9 2020
entrez: 14 7 2019
Statut: ppublish

Résumé

Lithocholic acid (2) was identified as the second endogenous ligand of vitamin D receptor (VDR), though its binding affinity to VDR and its vitamin D activity are very weak compared to those of the active metabolite of vitamin D

Identifiants

DOI: 10.1016/j.bmc.2019.07.003 PMID: 31300316
pubmed: 31300316
pii: S0968-0896(19)30931-9
doi: 10.1016/j.bmc.2019.07.003
pii:
doi:

Substances chimiques

Cholecalciferol 1C6V77QF41
Lithocholic Acid 5QU0I8393U

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3674-3681

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Hiroyuki Masuno (H)

Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan.

Yuko Kazui (Y)

Department of Chemistry, Faculty of Science, Ochanomizu University, 2-1-1 Otsuka, Bunkyo-ku, Tokyo 112-8610, Japan.

Aya Tanatani (A)

Department of Chemistry, Faculty of Science, Ochanomizu University, 2-1-1 Otsuka, Bunkyo-ku, Tokyo 112-8610, Japan. Electronic address: tanatani.aya@ocha.ac.jp.

Shinya Fujii (S)

Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan.

Emiko Kawachi (E)

Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan.

Teikichi Ikura (T)

Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.

Nobutoshi Ito (N)

Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.

Keiko Yamamoto (K)

Showa Pharmaceutical University, 3-3165 Higashi-Tamagawagakuen, Machidashi, Tokyo 194-8543, Japan.

Hiroyuki Kagechika (H)

Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan. Electronic address: kage.chem@tmd.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Development of novel lithocholic acid...
questionsmedicales.fr › Lipides › Lipides membranaires › Stérols › Cholécalciférol › Development of novel lithocholic acid...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Development of novel lithocholic acid...
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Cholanes › Acides choliques › Acide lithocholique › Development of novel lithocholic acid...