Integrative Genomic Characterization Identifies Molecular Subtypes of Lung Carcinoids.
Basic Helix-Loop-Helix Transcription Factors
/ genetics
Biomarkers, Tumor
/ genetics
Carcinoid Tumor
/ genetics
Cell Cycle
/ genetics
Cohort Studies
DNA Methylation
Epigenesis, Genetic
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Humans
Lung Neoplasms
/ genetics
Mutation
Proto-Oncogene Proteins
/ genetics
RNA, Messenger
/ genetics
Reproducibility of Results
S100 Proteins
/ metabolism
Journal
Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R
Informations de publication
Date de publication:
01 09 2019
01 09 2019
Historique:
received:
22
01
2019
revised:
03
06
2019
accepted:
09
07
2019
pubmed:
14
7
2019
medline:
17
6
2020
entrez:
14
7
2019
Statut:
ppublish
Résumé
Lung carcinoids (LC) are rare and slow growing primary lung neuroendocrine tumors. We performed targeted exome sequencing, mRNA sequencing, and DNA methylation array analysis on macro-dissected LCs. Recurrent mutations were enriched for genes involved in covalent histone modification/chromatin remodeling (34.5%;
Identifiants
pubmed: 31300474
pii: 0008-5472.CAN-19-0214
doi: 10.1158/0008-5472.CAN-19-0214
pmc: PMC6733269
mid: NIHMS1534890
doi:
Substances chimiques
ASCL1 protein, human
0
Basic Helix-Loop-Helix Transcription Factors
0
Biomarkers, Tumor
0
MEN1 protein, human
0
Proto-Oncogene Proteins
0
RNA, Messenger
0
S100 Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
4339-4347Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA072720
Pays : United States
Organisme : NIH HHS
ID : S10 OD012346
Pays : United States
Informations de copyright
©2019 American Association for Cancer Research.
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