Unlike the
Escherichia coli (E. coli)
Pyrococcus abyssi
Type 2 RNase H
abasic-ribose
archaea
bacteria
oxidative stress
oxidized-ribonucleotides
ribonuclease
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
30 08 2019
30 08 2019
Historique:
received:
23
05
2019
revised:
05
07
2019
pubmed:
14
7
2019
medline:
31
3
2020
entrez:
14
7
2019
Statut:
ppublish
Résumé
The presence of ribonucleoside monophosphates (rNMPs) in nuclear DNA decreases genome stability. To ensure survival despite rNMP insertions, cells have evolved a complex network of DNA repair mechanisms, in which the ribonucleotide excision repair pathway, initiated by type 2 RNase H (RNase HII/2), plays a major role. We recently demonstrated that eukaryotic RNase H2 cannot repair damage, that is, ribose monophosphate abasic (both apurinic or apyrimidinic) site (rAP) or oxidized rNMP embedded in DNA. Currently, it remains unclear why RNase H2 is unable to repair these modified nucleic acids having either only a sugar moiety or an oxidized base. Here, we compared the endoribonuclease specificity of the RNase HII enzymes from the archaeon
Identifiants
pubmed: 31300556
pii: S0021-9258(20)43241-7
doi: 10.1074/jbc.RA119.009493
pmc: PMC6721941
pii:
doi:
Substances chimiques
Ribonucleotides
0
Ribosemonophosphates
0
ribose-5-phosphate
4B2428FLTO
DNA
9007-49-2
ribonuclease HII
EC 3.1.26.-
Ribonuclease H
EC 3.1.26.4
Banques de données
PDB
['3O3F', '1IO2', '3PUF']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
13061-13072Subventions
Organisme : NIEHS NIH HHS
ID : R01 ES026243
Pays : United States
Organisme : Howard Hughes Medical Institute
ID : 55108574
Pays : United States
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