Simultaneous determination of eight constituents in rat plasma by HPLC-MS/MS and its application to a pharmacokinetic study after oral administration of Shejin-liyan Granule.
HPLC-MS/MS
Shejin-liyan Granule
pharmacokinetics
rat plasma
Journal
Biomedical chromatography : BMC
ISSN: 1099-0801
Titre abrégé: Biomed Chromatogr
Pays: England
ID NLM: 8610241
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
04
04
2019
revised:
26
06
2019
accepted:
09
07
2019
pubmed:
14
7
2019
medline:
16
1
2020
entrez:
14
7
2019
Statut:
ppublish
Résumé
Shejin-liyan Granule (SJLY) is an effective traditional Chinese prescription medicine for the treatment of acute pharyngitis. In this study, a selective and convenient HPLC-MS/MS method was developed and validated for the simultaneous determination of the following eight constituents in the plasma: galuteolin, tectoridin, tectorigenin, iridin, irigenin, irisflorentin, arctiin and arctigenin. The plasma samples were prepared by a protein precipitation method using acetonitrile, and analysis was carried out on a C
Substances chimiques
Drugs, Chinese Herbal
0
Isoflavones
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e4648Subventions
Organisme : Minhang municipal commission of health and family planning
ID : MW201858
Informations de copyright
© 2019 John Wiley & Sons, Ltd.
Références
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