Audio-visual and olfactory-visual integration in healthy participants and subjects with autism spectrum disorder.
Adolescent
Adult
Auditory Perception
/ physiology
Autism Spectrum Disorder
/ physiopathology
Bayes Theorem
Brain Mapping
Case-Control Studies
Child
Child, Preschool
Female
Humans
Magnetic Resonance Imaging
Male
Models, Neurological
Models, Psychological
Pleasure
Smell
/ physiology
Visual Perception
/ physiology
Young Adult
auditory-visual integration
autism spectrum disorder
dynamic causal modeling
fMRI
multisensory integration
olfactory-visual integration
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
15 10 2019
15 10 2019
Historique:
received:
04
02
2019
revised:
23
05
2019
accepted:
01
07
2019
pubmed:
14
7
2019
medline:
21
4
2020
entrez:
14
7
2019
Statut:
ppublish
Résumé
The human capacity to integrate sensory signals has been investigated with respect to different sensory modalities. A common denominator of the neural network underlying the integration of sensory clues has yet to be identified. Additionally, brain imaging data from patients with autism spectrum disorder (ASD) do not cover disparities in neuronal sensory processing. In this fMRI study, we compared the underlying neural networks of both olfactory-visual and auditory-visual integration in patients with ASD and a group of matched healthy participants. The aim was to disentangle sensory-specific networks so as to derive a potential (amodal) common source of multisensory integration (MSI) and to investigate differences in brain networks with sensory processing in individuals with ASD. In both groups, similar neural networks were found to be involved in the olfactory-visual and auditory-visual integration processes, including the primary visual cortex, the inferior parietal sulcus (IPS), and the medial and inferior frontal cortices. Amygdala activation was observed specifically during olfactory-visual integration, with superior temporal activation having been seen during auditory-visual integration. A dynamic causal modeling analysis revealed a nonlinear top-down IPS modulation of the connection between the respective primary sensory regions in both experimental conditions and in both groups. Thus, we demonstrate that MSI has shared neural sources across olfactory-visual and audio-visual stimulation in patients and controls. The enhanced recruitment of the IPS to modulate changes between areas is relevant to sensory perception. Our results also indicate that, with respect to MSI processing, adults with ASD do not significantly differ from their healthy counterparts.
Identifiants
pubmed: 31301203
doi: 10.1002/hbm.24715
pmc: PMC6865810
doi:
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4470-4486Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : IRTG 2150
Pays : International
Organisme : RWTH Aachen University
ID : START 17/14
Pays : International
Informations de copyright
© 2019 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc.
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