DNA Topoisomerase Inhibitors: Trapping a DNA-Cleaving Machine in Motion.

Anti-Bacterial Agents / pharmacology Catalytic Domain DNA / chemistry DNA Cleavage / drug effects DNA Gyrase / chemistry DNA Topoisomerases, Type I / chemistry DNA Topoisomerases, Type II / chemistry Fluoroquinolones / pharmacology Metals Models, Molecular Protein Conformation Quinolones Staphylococcus aureus / enzymology Topoisomerase II Inhibitors / pharmacology Topoisomerase Inhibitors / pharmacology
DNA cleavage DNA gyrase NBTIs antibiotics quinolones

Journal

Journal of molecular biology
ISSN: 1089-8638
Titre abrégé: J Mol Biol
Pays: Netherlands
ID NLM: 2985088R

Informations de publication

Date de publication:
23 08 2019
Historique:
received: 17 12 2018
revised: 24 06 2019
accepted: 02 07 2019
pubmed: 14 7 2019
medline: 11 6 2020
entrez: 14 7 2019
Statut: ppublish

Résumé

Type II topoisomerases regulate DNA topology by making a double-stranded break in one DNA duplex, transporting another DNA segment through this break and then resealing it. Bacterial type IIA topoisomerase inhibitors, such as fluoroquinolones and novel bacterial topoisomerase inhibitors, can trap DNA cleavage complexes with double- or single-stranded cleaved DNA. To study the mode of action of such compounds, 21 crystal structures of a "gyrase

Identifiants

DOI: 10.1016/j.jmb.2019.07.008 PMID: 31301408 PMC: PMC6723622
pubmed: 31301408
pii: S0022-2836(19)30432-2
doi: 10.1016/j.jmb.2019.07.008
pmc: PMC6723622
pii:
doi:

Substances chimiques

Anti-Bacterial Agents 0
Fluoroquinolones 0
Metals 0
Quinolones 0
Topoisomerase II Inhibitors 0
Topoisomerase Inhibitors 0
DNA 9007-49-2
DNA Topoisomerases, Type I EC 5.99.1.2
DNA Gyrase EC 5.99.1.3
DNA Topoisomerases, Type II EC 5.99.1.3

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

3427-3449

Subventions

Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/J004561/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UP_A025_1012
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/P012523/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/J/00000201
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 110072/Z/15/Z
Pays : United Kingdom

Informations de copyright

Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.

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Auteurs

Benjamin D Bax (BD)

Medicines Discovery Institute, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, UK. Electronic address: baxb@cardiff.ac.uk.

Garib Murshudov (G)

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.

Anthony Maxwell (A)

Dept. Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK.

Thomas Germe (T)

Dept. Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK. Electronic address: Thomas.Germe@jic.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › DNA Topoisomerase Inhibitors: Trapping a...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Éléments structuraux des protéines › Domaine catalytique › DNA Topoisomerase Inhibitors: Trapping a...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › DNA Topoisomerase Inhibitors: Trapping a...
questionsmedicales.fr › Phénomènes génétiques › Clivage de l'ADN › DNA Topoisomerase Inhibitors: Trapping a...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › DNA gyrase › DNA Topoisomerase Inhibitors: Trapping a...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Protéines liant le poly-adp-ribose › ADN topoisomérases de type I › DNA Topoisomerase Inhibitors: Trapping a...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Isomerases › DNA topoisomerases › ADN topoisomérases de type II › DNA Topoisomerase Inhibitors: Trapping a...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinoléines › Quinolinone › Fluoroquinolones › DNA Topoisomerase Inhibitors: Trapping a...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › DNA Topoisomerase Inhibitors: Trapping a...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › DNA Topoisomerase Inhibitors: Trapping a...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › DNA Topoisomerase Inhibitors: Trapping a...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinoléines › Quinolinone › DNA Topoisomerase Inhibitors: Trapping a...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Cocci à Gram positif › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › DNA Topoisomerase Inhibitors: Trapping a...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Inhibiteurs des topoisomérases › Inhibiteurs de la topoisomérase-II › DNA Topoisomerase Inhibitors: Trapping a...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Inhibiteurs des topoisomérases › DNA Topoisomerase Inhibitors: Trapping a...