Radiographically normal knees with contralateral joint space narrowing display greater change in cartilage transverse relaxation time than those with normal contralateral knees: a model of early OA? - data from the Osteoarthritis Initiative (OAI).
Cartilage T2
Cartilage composition
Cartilage transverse relaxation time
MRI
Model of early osteoarthritis
Journal
Osteoarthritis and cartilage
ISSN: 1522-9653
Titre abrégé: Osteoarthritis Cartilage
Pays: England
ID NLM: 9305697
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
04
02
2019
revised:
28
05
2019
accepted:
21
06
2019
pubmed:
14
7
2019
medline:
22
9
2020
entrez:
14
7
2019
Statut:
ppublish
Résumé
To develop a model of early osteoarthritis, by examining whether radiographically normal knees with contralateral joint space narrowing (JSN), but without contralateral trauma history, display greater longitudinal cartilage composition change (transverse relaxation time; T2) than subjects with bilaterally normal knees. 120 radiographically normal knees (Kellgren Lawrence grade [KLG] 0) from the Osteoarthritis Initiative were studied. 60 case knees displayed definite contralateral radiographic knee osteoarthritis (KLG ≥ 2) whereas 60 reference subjects were bilaterally KLG0, and were matched 1:1 to cases based on age, sex, and BMI. All had multi-echo spin-echo MRI acquired at year (Y) 1 and 4 follow-up, with cartilage T2 being determined in superficial and deep cartilage layers across 16 femorotibial subregions. T2 across all regions was considered the primary analytic focus. Of 60 KLG0 case knees (30 female, age: 65.0 ± 8.8 y, BMI: 27.6 ± 4.4 kg/m Radiographically normal knees with contralateral, non-traumatic JSN represent an applicable model of early osteoarthritis, with deep layer cartilage composition (T2) changing more rapidly than in bilaterally normal knees. CLINICALTRIALS. NCT00080171.
Identifiants
pubmed: 31301430
pii: S1063-4584(19)31132-X
doi: 10.1016/j.joca.2019.06.013
pmc: PMC6803071
mid: NIHMS1535784
pii:
doi:
Banques de données
ClinicalTrials.gov
['NCT00080171']
Types de publication
Journal Article
Observational Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1663-1668Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR052918
Pays : United States
Organisme : NIAMS NIH HHS
ID : P30 AR066262
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001422
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR065473
Pays : United States
Organisme : NIAMS NIH HHS
ID : P30 AR072579
Pays : United States
Organisme : NIAMS NIH HHS
ID : N01 AR022261
Pays : United States
Organisme : NIAMS NIH HHS
ID : N01 AR022259
Pays : United States
Organisme : NIAMS NIH HHS
ID : N01 AR022258
Pays : United States
Organisme : NIAMS NIH HHS
ID : N01 AR022260
Pays : United States
Informations de copyright
Copyright © 2019 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
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