Is resting state frontal alpha connectivity asymmetry a useful index to assess depressive symptoms? A preliminary investigation in a sample of university students.
Anxiety symptoms
Depressive symptoms
Frontal alpha asymmetry
Frontal alpha connectivity asymmetry
eLORETA
Journal
Journal of affective disorders
ISSN: 1573-2517
Titre abrégé: J Affect Disord
Pays: Netherlands
ID NLM: 7906073
Informations de publication
Date de publication:
01 10 2019
01 10 2019
Historique:
received:
25
03
2019
revised:
13
06
2019
accepted:
04
07
2019
pubmed:
14
7
2019
medline:
1
7
2020
entrez:
14
7
2019
Statut:
ppublish
Résumé
Frontal alpha asymmetry (FAA) has been widely investigated in depressive disorders (DDs) with contradictory and not conclusive results. The main aim of the current study was to explore the association between a new neurophysiological index, the so-called frontal alpha connectivity asymmetry index (FACA-I), and depressive symptoms. One hundred and thirteen participants (45 men and 68 women, mean age: 22.83 ± 2.26 years) were enrolled. Electroencephalographic (EEG) recordings were performed during 5 min of resting state (RS). FACA-I was computed by subtracting connectivity at left frontal regions from right frontal regions and dividing by their sum. RS FAA were also computed and compared to the FACA-I in all analyses. After controlling for the presence of potential confounding variables (i.e., sex, age and anxiety symptoms), only FACA-I scores between medial prefrontal cortex and subgenual anterior cingulate cortex were negatively associated with both somatic and cognitive/affective depressive symptoms and were lower in individuals with significant level of depressive symptoms. We focused on a sample of university students with no formal diagnosis of depression and we did not assess FAA and FACA-I during cognitive and/or emotional tasks, which make our interpretation specific to the RS condition. Taken together our data suggest that alpha connectivity asymmetry between medial prefrontal cortex and subgenual anterior cingulate cortex may be a useful neurophysiological index in the assessment of depressive symptoms.
Sections du résumé
BACKGROUND
Frontal alpha asymmetry (FAA) has been widely investigated in depressive disorders (DDs) with contradictory and not conclusive results. The main aim of the current study was to explore the association between a new neurophysiological index, the so-called frontal alpha connectivity asymmetry index (FACA-I), and depressive symptoms.
METHODS
One hundred and thirteen participants (45 men and 68 women, mean age: 22.83 ± 2.26 years) were enrolled. Electroencephalographic (EEG) recordings were performed during 5 min of resting state (RS). FACA-I was computed by subtracting connectivity at left frontal regions from right frontal regions and dividing by their sum. RS FAA were also computed and compared to the FACA-I in all analyses.
RESULTS
After controlling for the presence of potential confounding variables (i.e., sex, age and anxiety symptoms), only FACA-I scores between medial prefrontal cortex and subgenual anterior cingulate cortex were negatively associated with both somatic and cognitive/affective depressive symptoms and were lower in individuals with significant level of depressive symptoms.
LIMITATIONS
We focused on a sample of university students with no formal diagnosis of depression and we did not assess FAA and FACA-I during cognitive and/or emotional tasks, which make our interpretation specific to the RS condition.
CONCLUSIONS
Taken together our data suggest that alpha connectivity asymmetry between medial prefrontal cortex and subgenual anterior cingulate cortex may be a useful neurophysiological index in the assessment of depressive symptoms.
Identifiants
pubmed: 31301617
pii: S0165-0327(19)30769-4
doi: 10.1016/j.jad.2019.07.034
pii:
doi:
Types de publication
Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
152-159Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.