Sesquiterpene rich essential oil from Nepalese Bael tree (Aegle marmelos (L.) Correa) as potential antiproliferative agent.
Aegle marmelos
Anticancer
Essential oil
Sesquiterpene
β-caryophyllene
Journal
Fitoterapia
ISSN: 1873-6971
Titre abrégé: Fitoterapia
Pays: Netherlands
ID NLM: 16930290R
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
07
09
2018
revised:
09
07
2019
accepted:
10
07
2019
pubmed:
16
7
2019
medline:
4
12
2019
entrez:
15
7
2019
Statut:
ppublish
Résumé
Aegle marmelos (L.) Corr. (Rutaceae), also known as Bael tree, is an herbal traditional remedy in the South East Asia. In the present work, the leaf essential oil distilled from a population collected in Nepal was analyzed for the chemical composition by GC-MS showing different phytochemical constituents compared with literature data. The obtained oil was rich in sesquiterpenes, mainly β-Caryophyllene (26%), whereas monoterpenes, known in literature as the major components, were present in little amounts. Due to richness in sesquiterpenes which are promising as anticancer drugs, the oil was tested against several human tumor cell lines namely pancreatic (PSN-1), colon (LoVo), lung (H157) and ovarian (2008) cells showing IC
Identifiants
pubmed: 31302251
pii: S0367-326X(18)31517-X
doi: 10.1016/j.fitote.2019.104266
pii:
doi:
Substances chimiques
Antineoplastic Agents, Phytogenic
0
Oils, Volatile
0
Phytochemicals
0
Polycyclic Sesquiterpenes
0
Sesquiterpenes
0
caryophyllene
BHW853AU9H
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
104266Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.