Regulation of oral immune tolerance by the microbiome in food allergy.
Journal
Current opinion in immunology
ISSN: 1879-0372
Titre abrégé: Curr Opin Immunol
Pays: England
ID NLM: 8900118
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
22
04
2019
revised:
30
05
2019
accepted:
12
06
2019
pubmed:
16
7
2019
medline:
25
7
2020
entrez:
15
7
2019
Statut:
ppublish
Résumé
The steep rise in the incidence and prevalence of food allergy (FA) in the last few decades have focused attention of environmental mechanisms which act to promote disease, chief among which is the microbiome. Recent studies have now established the presence of pathogenic dysbiosis in FA that could be precipitated by a variety of environmental insults, including among others antibiotic usage and mode of delivery, that act to subvert the immune regulatory response that enforce tolerance to dietary antigens. A key attribute of this dysbiosis is the loss of Clostridial bacterial species that act to promote the formation of food allergen-specific nascent regulatory T cells in the gut. Significantly, different immunoprotective commensal bacteria, including members of the Clostridiales and Bacteroidales orders act to induce the transcription factor RORγt in nascent Treg cells via an upstream MyD88-dependent mechanism to promote tolerance to dietary antigens. Activation of this axis is disrupted by the dysbiosis, and can be restored by treatment with therapeutic microbiota. These findings highlight the potential for novel microbiota-based approaches to the prevention and treatment of the FA epidemic.
Identifiants
pubmed: 31302570
pii: S0952-7915(19)30035-4
doi: 10.1016/j.coi.2019.06.001
pmc: PMC6800633
mid: NIHMS1534426
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
141-147Subventions
Organisme : NIAID NIH HHS
ID : R01 AI126915
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI132843
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI117983
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.
Références
FEMS Microbiol Ecol. 2012 Jan;79(1):192-202
pubmed: 22029421
Science. 2015 Aug 28;349(6251):989-93
pubmed: 26160380
Nat Med. 2019 Jul;25(7):1164-1174
pubmed: 31235962
Nature. 2019 May;569(7754):126-130
pubmed: 30988509
JAMA Netw Open. 2019 Jan 4;2(1):e185630
pubmed: 30646188
Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13145-50
pubmed: 25157157
Cell Host Microbe. 2015 Feb 11;17(2):153-63
pubmed: 25620548
Nat Med. 2019 Mar;25(3):448-453
pubmed: 30643289
J Allergy Clin Immunol. 2016 Oct;138(4):1122-1130
pubmed: 27292825
Clin Exp Allergy. 2015 Mar;45(3):632-43
pubmed: 25599982
Immunity. 2015 Mar 17;42(3):512-23
pubmed: 25769611
Immunity. 2019 Jan 15;50(1):212-224.e4
pubmed: 30650377
Curr Opin Pediatr. 2016 Dec;28(6):748-753
pubmed: 27749359
Nat Med. 2016 Jul 7;22(7):713-22
pubmed: 27387886
Science. 2013 Aug 2;341(6145):569-73
pubmed: 23828891
Pediatrics. 2019 Mar;143(3):
pubmed: 30819972
J Allergy Clin Immunol. 2010 May;125(5):1128-1136.e8
pubmed: 20392476
Nature. 2016 Jul 06;535(7610):75-84
pubmed: 27383982
J Allergy Clin Immunol. 2007 Aug;120(2):343-50
pubmed: 17604093
Nature. 2013 Dec 19;504(7480):451-5
pubmed: 24226773
Nature. 2013 Aug 8;500(7461):232-6
pubmed: 23842501
Nat Immunol. 2016 May;17(5):545-55
pubmed: 27019226
J Allergy Clin Immunol. 2015 Jul;136(1):3-13
pubmed: 26145982
BMJ. 1989 Nov 18;299(6710):1259-60
pubmed: 2513902
Science. 2018 May 18;360(6390):795-800
pubmed: 29724905
Cell Rep. 2016 Jun 21;15(12):2809-24
pubmed: 27332875
Science. 2011 May 20;332(6032):974-7
pubmed: 21512004
Science. 2011 Jan 21;331(6015):337-41
pubmed: 21205640
Pediatr Allergy Immunol. 2010 Mar;21(2 Pt 2):e394-400
pubmed: 19889194
Nature. 2018 Feb 15;554(7692):373-377
pubmed: 29414937
J Allergy Clin Immunol. 2018 Apr;141(4):1334-1342.e5
pubmed: 28866384
Nat Rev Immunol. 2001 Oct;1(1):69-75
pubmed: 11905816
PLoS Biol. 2016 Aug 19;14(8):e1002533
pubmed: 27541692
Clin Exp Allergy. 2018 Jul;48(7):825-836
pubmed: 29700872
Immunity. 2017 Jul 18;47(1):32-50
pubmed: 28723552
Immunity. 2015 Aug 18;43(2):289-303
pubmed: 26231118
J Allergy Clin Immunol. 2013 Jan;131(1):201-12
pubmed: 23201093
J Allergy Clin Immunol. 2015 Mar;135(3):737-44.e8
pubmed: 25592987
Nature. 2013 Dec 19;504(7480):446-50
pubmed: 24226770
Science. 2015 Aug 28;349(6251):993-7
pubmed: 26272906