Novel antimycobacterial C-21 amide derivatives of the antibiotic fusidic acid: synthesis, pharmacological evaluation and rationalization of media-dependent activity using molecular docking studies in the binding site of human serum albumin.


Journal

MedChemComm
ISSN: 2040-2511
Titre abrégé: Medchemcomm
Pays: England
ID NLM: 101531525

Informations de publication

Date de publication:
01 Jun 2019
Historique:
received: 14 03 2019
accepted: 11 04 2019
entrez: 16 7 2019
pubmed: 16 7 2019
medline: 16 7 2019
Statut: epublish

Résumé

Fusidic acid is a natural product antibiotic used clinically, primarily against staphylococcal infections. It has also exhibited antimycobacterial activity against

Identifiants

pubmed: 31303994
doi: 10.1039/c9md00161a
pii: c9md00161a
pmc: PMC6596249
doi:

Types de publication

Journal Article

Langues

eng

Pagination

961-969

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Auteurs

Godwin Akpeko Dziwornu (GA)

Department of Chemistry , University of Cape Town , Rondebosch 7701 , South Africa . Email: Kelly.Chibale@uct.ac.za ; ; Tel: +27 21 6502553.

Stephanie Kamunya (S)

Department of Chemistry , University of Cape Town , Rondebosch 7701 , South Africa . Email: Kelly.Chibale@uct.ac.za ; ; Tel: +27 21 6502553.

Tando Ntsabo (T)

Institute of Infectious Disease and Molecular Medicine (IDM) , University of Cape Town , Rondebosch 7701 , South Africa.
Drug Discovery and Development Centre (H3D) , University of Cape Town , Rondebosch 7701 , South Africa.

Kelly Chibale (K)

Department of Chemistry , University of Cape Town , Rondebosch 7701 , South Africa . Email: Kelly.Chibale@uct.ac.za ; ; Tel: +27 21 6502553.
Institute of Infectious Disease and Molecular Medicine (IDM) , University of Cape Town , Rondebosch 7701 , South Africa.
Drug Discovery and Development Centre (H3D) , University of Cape Town , Rondebosch 7701 , South Africa.
South African Medical Research Council Drug Discovery and , Development Research Unit , University of Cape Town , Rondebosch 7701 , South Africa.

Classifications MeSH