Aortic stiffness is independently associated with interstitial myocardial fibrosis by native T1 and accelerated in the presence of chronic kidney disease.
Aortic stiffness
Chronic kidney disease
Native T1 mapping
Journal
International journal of cardiology. Heart & vasculature
ISSN: 2352-9067
Titre abrégé: Int J Cardiol Heart Vasc
Pays: Ireland
ID NLM: 101649525
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
26
03
2019
revised:
08
06
2019
accepted:
17
06
2019
entrez:
16
7
2019
pubmed:
16
7
2019
medline:
16
7
2019
Statut:
epublish
Résumé
Patients with chronic kidney disease (CKD) have considerable cardiovascular morbidity and mortality. Aortic stiffness is an independent predictor of cardiovascular risk and related to left ventricular remodeling and heart failure. Myocardial fibrosis is the pathophysiological hallmark of the failing heart. An observational study of consecutive CKD patients ( Aortic stiffness and interstitial myocardial fibrosis are interrelated; this association is accelerated in the presence of CKD, but independent of LGE. Our findings reiterate the significant contribution of CKD-related factors to the pathophysiology of cardiovascular remodeling.
Sections du résumé
BACKGROUND
BACKGROUND
Patients with chronic kidney disease (CKD) have considerable cardiovascular morbidity and mortality. Aortic stiffness is an independent predictor of cardiovascular risk and related to left ventricular remodeling and heart failure. Myocardial fibrosis is the pathophysiological hallmark of the failing heart.
METHODS AND RESULTS
RESULTS
An observational study of consecutive CKD patients (
CONCLUSIONS
CONCLUSIONS
Aortic stiffness and interstitial myocardial fibrosis are interrelated; this association is accelerated in the presence of CKD, but independent of LGE. Our findings reiterate the significant contribution of CKD-related factors to the pathophysiology of cardiovascular remodeling.
Identifiants
pubmed: 31304234
doi: 10.1016/j.ijcha.2019.100389
pii: S2352-9067(19)30081-8
pii: 100389
pmc: PMC6599886
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100389Déclaration de conflit d'intérêts
No conflict of interests.
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