Methylation of HPV 16 and EPB41L3 in oral gargles: Associations with oropharyngeal cancer detection and tumor characteristics.
Adult
Aged
Biomarkers, Tumor
/ genetics
Case-Control Studies
CpG Islands
/ genetics
DNA Methylation
DNA, Viral
/ genetics
Early Detection of Cancer
/ methods
Human papillomavirus 16
/ genetics
Humans
Male
Microfilament Proteins
/ genetics
Middle Aged
Mouth Mucosa
/ pathology
Oncogene Proteins, Viral
/ genetics
Oropharyngeal Neoplasms
/ diagnosis
Papillomavirus Infections
/ diagnosis
Proof of Concept Study
Sensitivity and Specificity
HPV
early detection
methylation
oropharyngeal cancer
screening
Journal
International journal of cancer
ISSN: 1097-0215
Titre abrégé: Int J Cancer
Pays: United States
ID NLM: 0042124
Informations de publication
Date de publication:
15 02 2020
15 02 2020
Historique:
received:
18
02
2019
revised:
05
06
2019
accepted:
18
06
2019
pubmed:
16
7
2019
medline:
3
4
2020
entrez:
16
7
2019
Statut:
ppublish
Résumé
Oropharyngeal cancer (OPC) incidence is increasing significantly among men and often requires intensive therapy causing significant morbidity. Early detection of OPC is needed, when monotherapy can be safely delivered with less treatment-associated morbidity, while maintaining high cure rates. We conducted a study of 101 pretreatment male OPC cases matched 1:1 to 101 disease-free controls for age and smoking history. Oral gargles were collected from cases and controls with additional biopsies or aspirates from cases. The HPV SPF
Identifiants
pubmed: 31304592
doi: 10.1002/ijc.32570
pmc: PMC7787351
mid: NIHMS1653126
doi:
Substances chimiques
Biomarkers, Tumor
0
DNA, Viral
0
EPB41L3 protein, human
0
Microfilament Proteins
0
Oncogene Proteins, Viral
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1018-1030Subventions
Organisme : NCI NIH HHS
ID : P30 CA076292
Pays : United States
Informations de copyright
© 2019 UICC.
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