Albendazole / chemistry Animals Anthelmintics / chemistry Cytochrome P-450 CYP1A1 / metabolism Liver / metabolism Metabolic Clearance Rate Microsomes, Liver / metabolism Monoterpenes Sheep Thymol / metabolism
Thymol albendazole hepatic metabolism sheep

Journal

Xenobiotica; the fate of foreign compounds in biological systems
ISSN: 1366-5928
Titre abrégé: Xenobiotica
Pays: England
ID NLM: 1306665

Informations de publication

Date de publication:
Apr 2020
Historique:
pubmed: 16 7 2019
medline: 1 4 2020
entrez: 16 7 2019
Statut: ppublish

Résumé

Combinations of bioactive phytochemicals with synthetic compounds have been suggested as promissory tools for the improvement of nematode control in livestock. Bioactive phytochemicals may interfere with the activity of drug-metabolizing enzymes and delay the metabolic conversion of anthelmintics into less potent metabolites.This research assessed the effect of the monoterpene thymol (TML) on the

Identifiants

DOI: 10.1080/00498254.2019.1644390 PMID: 31305200
pubmed: 31305200
doi: 10.1080/00498254.2019.1644390
doi:

Substances chimiques

Anthelmintics 0
Monoterpenes 0
Thymol 3J50XA376E
Cytochrome P-450 CYP1A1 EC 1.14.14.1
Albendazole F4216019LN

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

408-414

Auteurs

Victoria Miró (V)

Centro de Investigación Veterinaria de Tandil (CIVETAN-CONICET-CICPBA), Fac. Cs. Veterinarias, UNCPBA, Laboratorio de Farmacología, Departamento de Fisiopatología, Campus Universitario, Los Ombúes y Reforma Universitaria, Tandil, Argentina.

Adrian Lifschitz (A)

Centro de Investigación Veterinaria de Tandil (CIVETAN-CONICET-CICPBA), Fac. Cs. Veterinarias, UNCPBA, Laboratorio de Farmacología, Departamento de Fisiopatología, Campus Universitario, Los Ombúes y Reforma Universitaria, Tandil, Argentina.
ORCID: 0000-0001-7605-9744

Paula Viviani (P)

Centro de Investigación Veterinaria de Tandil (CIVETAN-CONICET-CICPBA), Fac. Cs. Veterinarias, UNCPBA, Laboratorio de Farmacología, Departamento de Fisiopatología, Campus Universitario, Los Ombúes y Reforma Universitaria, Tandil, Argentina.
ORCID: 0000-0002-7612-0792

Carolina Rocha (C)

Centro de Ciências Biológicas e da Saúde, Universidade Federal do Maranhão, Maranhao, Brazil.

Carlos Lanusse (C)

Centro de Investigación Veterinaria de Tandil (CIVETAN-CONICET-CICPBA), Fac. Cs. Veterinarias, UNCPBA, Laboratorio de Farmacología, Departamento de Fisiopatología, Campus Universitario, Los Ombúes y Reforma Universitaria, Tandil, Argentina.

Livio Costa (L)

Centro de Ciências Biológicas e da Saúde, Universidade Federal do Maranhão, Maranhao, Brazil.

Guillermo Virkel (G)

Centro de Investigación Veterinaria de Tandil (CIVETAN-CONICET-CICPBA), Fac. Cs. Veterinarias, UNCPBA, Laboratorio de Farmacología, Departamento de Fisiopatología, Campus Universitario, Los Ombúes y Reforma Universitaria, Tandil, Argentina.
ORCID: 0000-0002-0354-5001

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzimidazoles › Albendazole ›
questionsmedicales.fr › Eucaryotes › Animaux ›
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Anthelminthiques ›
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Cytochromes › Cytochrome P-450 enzyme system › Famille-1 de cytochromes P450 › Cytochrome P-450 CYP1A1 ›
questionsmedicales.fr › Système digestif › Foie ›
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Taux de clairance métabolique ›
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Microsomes › Microsomes du foie ›
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Monoterpènes ›
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Ruminants › Ovis ›
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Monoterpènes › Thymol ›