Effects of Educational Interventions on Human Papillomavirus Vaccine Acceptability: A Randomized Controlled Trial.
Journal
Obstetrics and gynecology
ISSN: 1873-233X
Titre abrégé: Obstet Gynecol
Pays: United States
ID NLM: 0401101
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
pubmed:
16
7
2019
medline:
24
3
2020
entrez:
16
7
2019
Statut:
ppublish
Résumé
To estimate whether targeted educational interventions can increase human papillomavirus (HPV) vaccine acceptability and knowledge among young women. An exploratory phase of the study was conducted to determine baseline acceptance of the prophylactic HPV vaccine and barriers to acceptance. Based on the results of that phase of the study, a randomized controlled trial of women aged 12-26 at a single institution was completed. A sample size of at least 84 women in each of three study arms (control, educational handout, or educational video) was planned to detect a 20% difference in vaccine acceptability among arms. All participants completed a survey collecting data on demographics, HPV vaccine preferences, and HPV vaccine knowledge after completion of their randomization assignments. The primary outcome was HPV vaccine acceptability. The secondary outcome was HPV vaccine knowledge. From March 2017 through August 2017, 256 women were randomized to one of three study arms: control (n=85), educational handout (n=84), or educational video (n=87). Demographics were similar between study arms. Overall, 51.7% of participants in the educational video arm reported willingness to accept the HPV vaccine compared with 33.3% and 28.2% of participants in the educational handout and control arms, respectively (P<.01). Those in the educational video and handout arms had higher median HPV vaccine knowledge scores than those in the control arm (6 and 5 vs 3, P<.01). Both interventions were reported as helpful in learning (97.7% vs 92.9%, P=.15), but the educational video arm was more likely to be helpful in deciding on vaccination (86.2% vs 70.2%, P<.01). Targeted educational interventions increase HPV vaccine acceptability and knowledge among young women. Follow up studies are needed to determine whether these interventions also increase rates of vaccine uptake and series completion. Clinicaltrials.gov, NCT03337269.
Identifiants
pubmed: 31306313
doi: 10.1097/AOG.0000000000003379
pii: 00006250-201908000-00024
doi:
Substances chimiques
Papillomavirus Vaccines
0
Banques de données
ClinicalTrials.gov
['NCT03337269']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
376-384Références
Walboomers JM, Jacobs MV, Manos MM, Bosch FX, Kummer JA, Shah KV, et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol 1999;189:12–9.
Bosch FX, Lorincz A, Munoz N, Meijer CJ, Shah KV. The causal relation between human papillomavirus and cervical cancer. J Clin Pathol 2002;55:244–65.
FUTURE II Study Group. Quadrivalent vaccine against human papillomavirus to prevent high-grade cervical lesions. N Engl J Med 2007;356:1915–27.
Huh WK, Joura EA, Giuliano AR, Iversen OE, de Andrade RP, Ault KA, et al. Final efficacy, immunogenicity, and safety analyses of a nine-valent human papillomavirus vaccine in women aged 16-26 years: a randomised, double-blind trial. Lancet 2017;390:2143–59.
Markowitz LE, Singleton JA, Elam-Evans LD, Curtis CR, MacNeil J, Jeyarajah J, et al. National, regional, state, and selected local area vaccination coverage among adolescents aged 13–17 years—United States, 2015. MMWR Morb Mortal Wkly Rep 2016;65:850–8.
Walker TY, Elam-Evans LD, Singleton JA, Yankey D, Markowitz LE, Fredua B, et al. National, regional, state, and selected local area vaccination coverage among adolescents aged 13–17 years—United States, 2016. MMWR Morb Mortal Wkly Rep 2017;66:874–82.
Jemal A, Simard EP, Dorell C, Noone A, Markowitz LE, Kohler B, et al. Annual report to the nation on the status of cancer, 1975–2009, featuring the burden and trends in human papillomavirus (HPV)-associated cancers and HPV vaccination coverage levels. J Natl Cancer Inst 2013;105:175–201.
Kahn J, Lan D, Kahn R. Sociodemographic factors associated with high-risk human papillomavirus infection. Obstet Gynecol 2007;110:87–95.
Gelman A, Miller E, Schwarz EB, Akers AY, Jeong K, Borrero S. Racial disparities in human papillomavirus vaccination: does access matter? J Adolesc Health 2013;53:756–62.
Okafor C, Hu X, Cook R. Racial/ethnic disparities in HPV vaccine uptake among a sample of college women. J Racial Ethnic Health Disparities 2015;2:311–6.
Reiter PL, Stubbs B, Panozzo CA, Whitesell D, Brewer NT. HPV and HPV vaccine education intervention: effects on parents, healthcare staff, and school staff. Cancer Epidemiol Biomarkers Prev 2011;20:2354–61.
Loke AY, Kwan ML, Wong Y, Wong AKY. The uptake of human papillomavirus vaccination and its associated factors among adolescents: a systematic review. J Prim Care Community Health 2017;8:349–62.
Cartmell K, Young-Pierce J, McGue S, Alberg A, Luque J, Zubizarreta M, et al. Barriers, facilitators, and potential strategies for increasing HPV vaccination: a statewide assessment to inform action. Papillomarvirus Res 2018;5:21–31.
Hirth JM, Batuuka DN, Gross TT, Cofie L, Berenson AB. Human papillomavirus vaccine motivators and barriers among community college students: considerations for development of a successful vaccination program. Vaccine 2018;36:1032–7.
Staples JN, Wong MS, Rimel BJ. An educational intervention to improve human papilloma virus (HPV) and cervical cancer knowledge among African American college students. Gynecol Oncol 2018;149:101–5.
Rao BA, Seshadri JG, Thirthahalli C. Impact of health education on HPV vaccination. Indian J Gynecol Oncol 2017;15:41.
Suarez MA, Madrigal JM, Jordan L, Patel A. Effectiveness of an educational intervention to increase human papillomavirus knowledge in high-risk minority women. J Low Genit Tract Dis 2018;22:288–94.
Adjei Boakye E, Tobo BB, Rojek RP, Mohammed KA, Geneus CJ, Osazuwa-Peters N. Approaching a decade since HPV vaccine licensure: racial and gender disparities in knowledge and awareness of HPV and HPV vaccine. Hum Vaccin Immunother 2017;13:2713–22.
Tiro JA, Tsui J, Bauer HM, Yamada E, Kobrin S, Breen N. Human papillomavirus vaccine use among adolescent girls and young adult women: an analysis of the 2007 California Health Interview Survey. J Womens Health 2012;21:656–65.