Decellularized extracellular matrix gelloids support mesenchymal stem cell growth and function in vitro.
Animals
Cattle
Cell Differentiation
/ drug effects
Cell Proliferation
/ drug effects
Cell Survival
/ drug effects
DNA
/ metabolism
Extracellular Matrix
/ metabolism
Gelatin
/ pharmacology
Mesenchymal Stem Cells
/ cytology
Muscle Development
/ drug effects
Osteogenesis
/ drug effects
Solubility
Swine
extracellular matrix
gelatin
gelloids
mesenchymal stem cells
skeletal muscle
stem cell differentiation
Journal
Journal of tissue engineering and regenerative medicine
ISSN: 1932-7005
Titre abrégé: J Tissue Eng Regen Med
Pays: England
ID NLM: 101308490
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
04
02
2019
revised:
10
06
2019
accepted:
03
07
2019
pubmed:
16
7
2019
medline:
17
7
2020
entrez:
16
7
2019
Statut:
ppublish
Résumé
Volumetric muscle loss (VML) injuries are irrecoverable due to a significant loss of regenerative elements, persistent inflammation, extensive fibrosis, and functional impairment. When used in isolation, previous stem cell and biomaterial-based therapies have failed to regenerate skeletal muscle at clinically relevant levels. The extracellular matrix (ECM) microenvironment is crucial for the viability, stemness, and differentiation of stem cells. Decellularized-ECM (D-ECM) scaffolds are at the forefront of ongoing research to develop a viable therapy for VML. Due to the retention of key ECM components, D-ECM scaffolds provide an excellent substrate for the adhesion and migration of several cell types. Mesenchymal stem cells (MSCs) possess regenerative and immunomodulatory properties and are currently under investigation in clinical trials for a wide range of medical conditions. However, a major limitation to the use of MSCs in clinical applications is their poor viability at the site of transplantation. In this study, we have fabricated spherical scaffolds composed of gelatin and skeletal muscle D-ECM for the adhesion and delivery of MSCs to the site of VML injury. These spherical scaffolds termed "gelloids" supported MSC survival, expansion, trophic factor secretion, immunomodulation, and myogenic protein expression in vitro. Future studies would determine the therapeutic efficacy of this approach in a murine model of VML injury.
Substances chimiques
Gelatin
9000-70-8
DNA
9007-49-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1830-1842Informations de copyright
© 2019 John Wiley & Sons, Ltd.
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