Effects of bifenthrin on sex differentiation in Japanese Medaka (Oryzias latipes).

Animals Estradiol Oryzias / physiology Pyrethrins / toxicity Sex Differentiation / drug effects Water Pollutants, Chemical / toxicity
Developmental toxicity Endocrine disrupting compounds Estrogenic pathway Japanese medaka Pyrethroids Sex differentiation

Journal

Environmental research
ISSN: 1096-0953
Titre abrégé: Environ Res
Pays: Netherlands
ID NLM: 0147621

Informations de publication

Date de publication:
10 2019
Historique:
received: 05 02 2019
revised: 13 05 2019
accepted: 28 06 2019
pubmed: 16 7 2019
medline: 1 5 2020
entrez: 16 7 2019
Statut: ppublish

Résumé

Bifenthrin (BF) is a pyrethroid insecticide used in urban and agricultural applications. Previous studies in early life stages of fish have indicated anti-estrogenic activity; however, estrogenic activity has been observed in adults. To test the hypothesis that BF impairs sex differentiation, larval Japanese Medaka were exposed to BF during a critical developmental window for phenotypic sexual differentiation. Fish were exposed to environmentally relevant concentrations of BF (0.15 μg/L and 1.5 μg/L), a single concentration (0.3 mg/L) of an estrogen receptor (ER) antagonist (ICI 182,780), and an ER agonist (0.2 ug/L) (17β-estradiol). Fish were exposed at 8 days post hatch (dph) larvae for 30 days. Phenotypic sex, secondary sexual characteristics (SSC) and genotypic sex were investigated at sexual maturity (8 weeks). A trend towards masculinization (p = 0.06) based on the presence of papillary processes in anal fin rays of Japanese Medaka was observed in fish exposed to the lowest concentration of BF. However, genotypic gender ratios were not altered. These results show sex differentiation was not significantly altered by larval exposure to BF in Japanese medaka.

Identifiants

DOI: 10.1016/j.envres.2019.108564 PMID: 31306987
pubmed: 31306987
pii: S0013-9351(19)30361-5
doi: 10.1016/j.envres.2019.108564
pii:
doi:

Substances chimiques

Pyrethrins 0
Water Pollutants, Chemical 0
Estradiol 4TI98Z838E
bifenthrin 6B66JED0KN

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

108564

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Luísa Becker Bertotto (LB)

Environmental Toxicology Graduate Program, University of California, Riverside, CA, 92521, USA; Department of Environmental Sciences, University of California, Riverside, CA, 92521, USA. Electronic address: lbeck006@ucr.edu.

Richard Bruce (R)

Department of Environmental Sciences, University of California, Riverside, CA, 92521, USA; School of Biological Sciences, Plymouth University, PL4 8AA, UK.

Shuying Li (S)

Institute of Pesticide and Environmental Toxicology, Zhejiang University, Hangzhou, 310058, PR China.

Jaben Richards (J)

Department of Environmental Sciences, University of California, Riverside, CA, 92521, USA.

Rafid Sikder (R)

Department of Environmental Sciences, University of California, Riverside, CA, 92521, USA.

Luka Baljkas (L)

Department of Environmental Sciences, University of California, Riverside, CA, 92521, USA.

Marissa Giroux (M)

Environmental Toxicology Graduate Program, University of California, Riverside, CA, 92521, USA; Department of Environmental Sciences, University of California, Riverside, CA, 92521, USA.

Jay Gan (J)

Department of Environmental Sciences, University of California, Riverside, CA, 92521, USA.

Daniel Schlenk (D)

Environmental Toxicology Graduate Program, University of California, Riverside, CA, 92521, USA; Department of Environmental Sciences, University of California, Riverside, CA, 92521, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Effects of bifenthrin on sex differentiation...
questionsmedicales.fr › Hormones gonadiques › Hormones sexuelles stéroïdiennes › Congénères de l'oestradiol › Oestradiol › Effects of bifenthrin on sex differentiation...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Smegmamorpha › Beloniformes › Oryzias › Effects of bifenthrin on sex differentiation...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Monoterpènes › Cyclopentane monoterpenes › Pyréthrines › Effects of bifenthrin on sex differentiation...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Développement sexuel › Différenciation sexuelle › Effects of bifenthrin on sex differentiation...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Polluants environnementaux › Polluants de l'eau › Polluants chimiques de l'eau › Effects of bifenthrin on sex differentiation...