Osteoblast-derived NOTUM reduces cortical bone mass in mice and the
WNT16
osteoporosis
transgenic
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
pubmed:
17
7
2019
medline:
26
5
2020
entrez:
17
7
2019
Statut:
ppublish
Résumé
Osteoporosis is a common skeletal disease, affecting millions of individuals worldwide. Currently used osteoporosis treatments substantially reduce vertebral fracture risk, whereas nonvertebral fracture risk, mainly caused by reduced cortical bone mass, has only moderately been improved by the osteoporosis drugs used, defining an unmet medical need. Because several wingless-type MMTV integration site family members (WNTs) and modulators of WNT activity are major regulators of bone mass, we hypothesized that NOTUM, a secreted WNT lipase, might modulate bone mass
Identifiants
pubmed: 31307226
doi: 10.1096/fj.201900707R
pmc: PMC6766646
doi:
Substances chimiques
Wnt Proteins
0
Esterases
EC 3.1.-
Notum protein, human
EC 3.1.1.-
Notum protein, mouse
EC 3.1.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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