Biomarkers of drug-induced liver injury.
Acetaminophen
Diagnosis
Drug regulation
Hepatotoxicity
Idiosyncratic drug-induced liver injury
Predictive value
Prognosis
Journal
Advances in pharmacology (San Diego, Calif.)
ISSN: 1557-8925
Titre abrégé: Adv Pharmacol
Pays: United States
ID NLM: 9015397
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
17
7
2019
pubmed:
17
7
2019
medline:
13
2
2020
Statut:
ppublish
Résumé
Drug-induced liver injury (DILI) is a major clinical and regulatory challenge. As a result, interest in DILI biomarkers is growing. So far, considerable progress has been made in identification of biomarkers for diagnosis (acetaminophen-cysteine protein adducts), prediction (genetic biomarkers), and prognosis (microRNA-122, high mobility group box 1 protein, keratin-18, glutamate dehydrogenase, mitochondrial DNA). Many of those biomarkers also provide mechanistic insight. The purpose of this chapter is to review major advances in DILI biomarker research over the last decade, and to highlight some of the challenges involved in implementation. Although much work has been done, more liver-specific biomarkers, more DILI-specific biomarkers, and better prognostic biomarkers for survival are all still needed. Furthermore, more work is needed to define reference intervals and medical decision limits.
Identifiants
pubmed: 31307588
pii: S1054-3589(19)30009-2
doi: 10.1016/bs.apha.2019.02.001
pmc: PMC7351790
mid: NIHMS1599892
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
221-239Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM103549
Pays : United States
Organisme : NIGMS NIH HHS
ID : P30 GM118247
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK102142
Pays : United States
Informations de copyright
© 2019 Elsevier Inc. All rights reserved.
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