Mechanisms and biomarkers of liver regeneration after drug-induced liver injury.
Acetaminophen
Acute liver failure
Alcohol
Carbon tetrachloride
Cytokines
Drug-induced liver injury
Growth factors
Hepatocyte proliferation
Ischemic hepatitis
Liver repair
Journal
Advances in pharmacology (San Diego, Calif.)
ISSN: 1557-8925
Titre abrégé: Adv Pharmacol
Pays: United States
ID NLM: 9015397
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
17
7
2019
pubmed:
17
7
2019
medline:
13
2
2020
Statut:
ppublish
Résumé
Liver, the major metabolic organ in the body, is known for its remarkable capacity to regenerate. Whereas partial hepatectomy (PHx) is a popular model for the study of liver regeneration, the liver also regenerates after acute injury, but less is known about the mechanisms that drive it. Recent studies have shown that liver regeneration is critical for survival in acute liver failure (ALF), which is usually due to drug-induced liver injury (DILI). It is sometimes assumed that the signaling pathways involved are similar to those that regulate regeneration after PHx, but there are likely to be critical differences. A better understanding of regeneration mechanisms after DILI and hepatotoxicity in general could lead to development of new therapies for ALF patients and new biomarkers to predict patient outcome. Here, we summarize what is known about the mechanisms of liver regeneration and repair after hepatotoxicity. We also review the literature in the emerging field of liver regeneration biomarkers.
Identifiants
pubmed: 31307589
pii: S1054-3589(19)30014-6
doi: 10.1016/bs.apha.2019.03.001
pmc: PMC7641498
mid: NIHMS1639530
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
241-262Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM103549
Pays : United States
Organisme : NIGMS NIH HHS
ID : P30 GM118247
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK098414
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM106999
Pays : United States
Informations de copyright
© 2019 Elsevier Inc. All rights reserved.
Références
Toxicol Appl Pharmacol. 1988 May;93(3):378-87
pubmed: 3368917
Transplant Proc. 2004 Oct;36(8):2359-61
pubmed: 15561249
Eur J Biochem. 1990 Oct 24;193(2):375-81
pubmed: 2146117
Hepatology. 1995 Feb;21(2):477-86
pubmed: 7843722
Toxicol Appl Pharmacol. 2012 Nov 1;264(3):387-94
pubmed: 22980195
J Cell Physiol. 2007 Nov;213(2):556-63
pubmed: 17620325
Am J Physiol Gastrointest Liver Physiol. 2015 Mar 1;308(5):G364-77
pubmed: 25414100
Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4477-82
pubmed: 15070743
Hepatology. 1993 Dec;18(6):1422-31
pubmed: 8244268
J Surg Res. 2007 Nov;143(1):13-9
pubmed: 17655862
FASEB J. 1995 Feb;9(2):240-5
pubmed: 7781926
Am J Med. 2015 Dec;128(12):1314-21
pubmed: 26299319
J Biol Chem. 2008 May 16;283(20):13565-77
pubmed: 18337250
Am J Pathol. 1998 Jun;152(6):1577-89
pubmed: 9626061
Liver. 1992 Jun;12(3):132-6
pubmed: 1380112
Basic Clin Pharmacol Toxicol. 2012 Dec;111(6):417-25
pubmed: 22900545
Gut. 1982 Jan;23(1):8-13
pubmed: 7056500
J Biol Chem. 2009 May 8;284(19):12917-23
pubmed: 19286661
Toxicol Pathol. 2004 Sep-Oct;32(5):567-76
pubmed: 15603541
Biochem Pharmacol. 1991 Nov 27;42(12):2323-32
pubmed: 1764117
Pediatr Transplant. 2009 Mar;13(2):223-30
pubmed: 18643912
Toxicol Appl Pharmacol. 2011 Mar 15;251(3):226-33
pubmed: 21241727
Pharm Res. 2013 Sep;30(9):2174-87
pubmed: 23462933
Clin Biochem. 1999 Oct;32(7):571-8
pubmed: 10614720
Clin Med (Lond). 2015 Jun;15(3):244-7
pubmed: 26031973
Hepatology. 2011 Mar;53(3):974-82
pubmed: 21319200
Biochem Biophys Res Commun. 2003 Apr 25;304(1):207-12
pubmed: 12705907
J Hepatol. 1994 Jan;20(1):106-11
pubmed: 8201209
Toxicol Pathol. 2005;33(1):41-51
pubmed: 15805055
Alcohol. 2007 Jun;41(4):271-80
pubmed: 17630087
Basic Clin Pharmacol Toxicol. 2005 Jul;97(1):8-14
pubmed: 15943753
PLoS One. 2016 Jan 25;11(1):e0147864
pubmed: 26808690
Hepatology. 2005 Dec;42(6):1364-72
pubmed: 16317692
J Clin Invest. 2012 Apr;122(4):1574-83
pubmed: 22378043
Hepatology. 2014 Oct;60(4):1336-45
pubmed: 24923598
Transplant Proc. 2004 Oct;36(8):2357-8
pubmed: 15561248
Proc Soc Exp Biol Med. 1959 Oct-Dec;102:672-5
pubmed: 14415256
Toxicol Appl Pharmacol. 2015 Dec 1;289(2):213-22
pubmed: 26431796
EXCLI J. 2016 Dec 15;15:817-828
pubmed: 28337112
Am J Pathol. 2017 Mar;187(3):543-552
pubmed: 28068511
Expert Rev Gastroenterol Hepatol. 2014 Nov;8(8):897-907
pubmed: 24964729
Biochem J. 1989 Sep 15;262(3):721-5
pubmed: 2590162
Gastroenterology. 1979 Sep;77(3):528-31
pubmed: 572315
Expert Opin Drug Metab Toxicol. 2015;11(11):1769-79
pubmed: 26190663
Mol Med Rep. 2018 Apr;17(4):5390-5395
pubmed: 29393448
Crit Rev Toxicol. 2003;33(2):105-36
pubmed: 12708612
Gastroenterology. 1989 Aug;97(2):439-45
pubmed: 2490426
Toxicol Appl Pharmacol. 2014 Sep 15;279(3):266-274
pubmed: 24905542
Dis Model Mech. 2016 Nov 1;9(11):1383-1396
pubmed: 27562099
Dose Response. 2017 Jan 30;15(1):1559325817690287
pubmed: 28210203
Gastroenterology. 1996 Jun;110(6):1854-62
pubmed: 8964411
Food Chem Toxicol. 2018 May;115:273-283
pubmed: 29534981
Hepatology. 2005 Jan;41(1):26-31
pubmed: 15690478
Liver Transpl. 2016 Apr;22(4):505-15
pubmed: 26421889
Toxicol Appl Pharmacol. 2003 Sep 15;191(3):211-26
pubmed: 13678654
Eur J Clin Invest. 2008 May;38(5):306-16
pubmed: 18371088
Toxicol Sci. 2017 Feb;155(2):363-378
pubmed: 28123000
Hepatology. 2000 Apr;31(4):864-71
pubmed: 10733541
Gastroenterology. 2006 Jul;131(1):165-78
pubmed: 16831600
Ann Intern Med. 2002 Dec 17;137(12):947-54
pubmed: 12484709
Toxicol Sci. 2006 Nov;94(1):217-25
pubmed: 16896059
Liver Transpl. 2006 Dec;12(12):1776-81
pubmed: 17133565
Arch Toxicol. 1989;63(5):367-75
pubmed: 2479360
J Pharmacol Exp Ther. 2010 Jul;334(1):33-43
pubmed: 20363854
Am J Pathol. 2014 Nov;184(11):3013-25
pubmed: 25193591
Am J Gastroenterol. 2018 Sep;113(9):1319
pubmed: 29946176
J Clin Transl Res. 2017 Nov 18;3(3):297-310
pubmed: 30895271
Hepatology. 2006 Aug;44(2):379-88
pubmed: 16871587
Toxicol Lett. 1989 Dec;49(2-3):215-41
pubmed: 2481348
Semin Liver Dis. 2008 May;28(2):142-52
pubmed: 18452114
Am J Physiol. 1992 Oct;263(4 Pt 1):G579-85
pubmed: 1415718
Hepatology. 2019 Feb;69(2):760-773
pubmed: 29357190
Metabolites. 2013 Aug 02;3(3):606-22
pubmed: 24958141
Science. 1996 Nov 22;274(5291):1379-83
pubmed: 8910279
J Pathol. 1998 Jul;185(3):298-302
pubmed: 9771484
J Hepatol. 2000;32(1 Suppl):19-31
pubmed: 10728791
Arch Intern Med. 1981 Feb 23;141(3 Spec No):380-5
pubmed: 7469629
Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1441-6
pubmed: 9037072
Toxicology. 1997 Mar 28;118(2-3):181-93
pubmed: 9129172
Compr Physiol. 2013 Jan;3(1):485-513
pubmed: 23720294
Am J Physiol Gastrointest Liver Physiol. 2006 Jul;291(1):G102-9
pubmed: 16565415
Hepatology. 2017 Apr;65(4):1384-1392
pubmed: 27997988
J Hepatol. 2012 May;56(5):1070-1079
pubmed: 22266604
Am J Physiol Gastrointest Liver Physiol. 2016 Nov 1;311(5):G794-G806
pubmed: 27634014
Free Radic Res. 2011 Feb;45(2):156-64
pubmed: 20942566
Exp Biol Med (Maywood). 2018 Feb;243(3):300-307
pubmed: 29096561
Biochim Biophys Acta Mol Basis Dis. 2019 May 1;1865(5):1031-1039
pubmed: 31007174
Chem Res Toxicol. 2002 Dec;15(12):1504-13
pubmed: 12482232
Environ Health Perspect. 1995 Mar;103(3):260-7
pubmed: 7768227
Clin Pharmacol Ther. 2017 Dec;102(6):961-969
pubmed: 28419467
Toxicol Sci. 2017 Jan;155(1):61-74
pubmed: 27655350
Toxicol Sci. 2002 Jun;67(2):322-8
pubmed: 12011492
Toxicol Pathol. 1991;19(1):47-58
pubmed: 2047707
Biochem Biophys Res Commun. 2003 Oct 3;309(4):857-63
pubmed: 13679052
Am J Pathol. 2012 Jun;180(6):2321-9
pubmed: 22507835
Hepatology. 2004 Nov;40(5):1170-9
pubmed: 15486922
Environ Toxicol Pharmacol. 2004 Nov;18(2):149-60
pubmed: 21782744
Am J Pathol. 2009 Sep;175(3):1056-65
pubmed: 19679878
Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1570-5
pubmed: 17242348
Am J Pathol. 2013 Nov;183(5):1518-1526
pubmed: 24007882
Lab Invest. 2007 Oct;87(10):1018-28
pubmed: 17660847
Toxicol Pathol. 1989;17(3):494-505
pubmed: 2814225
Toxicol Pathol. 1987;15(4):431-8
pubmed: 3432943
Toxicol Sci. 2008 Aug;104(2):419-27
pubmed: 18469330
Biochem J. 1998 Sep 15;334 ( Pt 3):669-76
pubmed: 9729476
J Pharmacol Exp Ther. 2005 Feb;312(2):509-16
pubmed: 15466245
DNA Cell Biol. 2004 Sep;23(9):592-603
pubmed: 15383179
Clin Gastroenterol Hepatol. 2019 May;17(6):1201-1203
pubmed: 30103039
Ann Hepatol. 2016 Sep-Oct;15(5):762-72
pubmed: 27493116