Long-acting or extended-release antiretroviral products for HIV treatment and prevention in infants, children, adolescents, and pregnant and breastfeeding women: knowledge gaps and research priorities.
Journal
The lancet. HIV
ISSN: 2352-3018
Titre abrégé: Lancet HIV
Pays: Netherlands
ID NLM: 101645355
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
07
11
2018
revised:
14
03
2019
accepted:
04
04
2019
pubmed:
17
7
2019
medline:
9
6
2020
entrez:
17
7
2019
Statut:
ppublish
Résumé
Antiretroviral agents with long-acting properties have potential to improve treatment outcomes substantially for people living with HIV. In November 2017, the Long acting/Extended Release Antiretroviral Resource Program (LEAP) convened a workshop with the aim of shaping the research agenda and promoting early development of long-acting or extended release products for key populations: pregnant and lactating women, children aged up to 10 years, and adolescents aged 10-19 years. Goals included strategies and principles to ensure that the needs of children, adolescents, and pregnant and lactating women are considered when developing long-acting formulations. Research should focus not only on how best to transition long-acting products to these populations, but also on early engagement across sectors and among stakeholders. A parallel rather than sequential approach is needed when establishing adult, adolescent, and paediatric clinical trials and seeking regulatory approval. Pregnant and lactating women should be included in adult clinical trials. Adolescent-friendly trial design is needed to improve recruitment and retention of young people.
Identifiants
pubmed: 31307946
pii: S2352-3018(19)30147-X
doi: 10.1016/S2352-3018(19)30147-X
pmc: PMC7152795
pii:
doi:
Substances chimiques
Anti-Retroviral Agents
0
Delayed-Action Preparations
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e552-e558Subventions
Organisme : NICHD NIH HHS
ID : HHSN275201800001C
Pays : United States
Organisme : NICHD NIH HHS
ID : HHSN275201800001I
Pays : United States
Organisme : NIAID NIH HHS
ID : R24 AI118397
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI106716
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.
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