Repurposing Quinacrine against Ebola Virus Infection
Animals
Antimalarials
/ pharmacology
Antiviral Agents
/ pharmacology
Caco-2 Cells
Chlorocebus aethiops
Disease Models, Animal
Drug Repositioning
Ebolavirus
/ drug effects
HeLa Cells
Hemorrhagic Fever, Ebola
/ drug therapy
Humans
Mice
Mice, Inbred BALB C
Microbial Sensitivity Tests
Quinacrine
/ pharmacology
Survival Analysis
Tilorone
/ pharmacology
Vero Cells
Viral Load
/ drug effects
Ebola virus
Ebola virus disease
antiviral
quinacrine
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
03
06
2019
accepted:
02
07
2019
pubmed:
17
7
2019
medline:
4
7
2020
entrez:
17
7
2019
Statut:
epublish
Résumé
Quinacrine hydrochloride is a small-molecule, orally bioavailable drug that has been used clinically as an antimalarial and for many other applications. A machine learning model trained on Ebola virus (EBOV) screening data identified quinacrine as a potent (nanomolar)
Identifiants
pubmed: 31307979
pii: AAC.01142-19
doi: 10.1128/AAC.01142-19
pmc: PMC6709481
pii:
doi:
Substances chimiques
Antimalarials
0
Antiviral Agents
0
Quinacrine
H0C805XYDE
Tilorone
O6W7VEW6KS
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : HHSN272201000040C
Pays : United States
Organisme : NIAID NIH HHS
ID : HHSN272201000040I
Pays : United States
Organisme : NCATS NIH HHS
ID : R21 TR001718
Pays : United States
Informations de copyright
Copyright © 2019 American Society for Microbiology.
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