The transcription factor Hey and nuclear lamins specify and maintain cell identity.
D. melanogaster
ageing
cell biology
cell identity
gene regulation
hey
lamin
nuclear organization
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
16 07 2019
16 07 2019
Historique:
received:
30
12
2018
accepted:
03
07
2019
entrez:
17
7
2019
pubmed:
17
7
2019
medline:
18
12
2019
Statut:
epublish
Résumé
The inability of differentiated cells to maintain their identity is a hallmark of age-related diseases. We found that the transcription factor Hey supervises the identity of differentiated enterocytes (ECs) in the adult
Identifiants
pubmed: 31310235
doi: 10.7554/eLife.44745
pii: 44745
pmc: PMC6634966
doi:
pii:
Substances chimiques
Basic Helix-Loop-Helix Transcription Factors
0
Drosophila Proteins
0
Hey protein, Drosophila
0
Lamins
0
Banques de données
GEO
['GSE87896', 'GSE112640', 'GSE22069']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Israel Academy of Sciences and Humanities
ID : 739/15
Pays : International
Organisme : Deutsche Forschungsgemeinschaft
ID : SBF 688
Pays : International
Organisme : Flinkman-Marandy Cancer Research Grant
ID : 0001
Pays : International
Organisme : Deutsche Forschungsgemeinschaft
ID : TPA 16
Pays : International
Informations de copyright
© 2019, Flint Brodsly et al.
Déclaration de conflit d'intérêts
NF, EB, OB, AS, MM, MG, CD, HR, AO No competing interests declared
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