Overproduction of endothelin-1 impairs glucose tolerance but does not promote visceral adipose tissue inflammation or limit metabolic adaptations to exercise.
Animals
Body Mass Index
Endothelin-1
/ antagonists & inhibitors
Exercise
/ physiology
Female
Gene Expression
Glucose Intolerance
/ metabolism
Humans
Inflammation
/ pathology
Intra-Abdominal Fat
/ pathology
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, Obese
Obesity
/ pathology
Physical Conditioning, Animal
/ physiology
Running
adipose tissue
endothelin-1
exercise
glucose control
inflammation
Journal
American journal of physiology. Endocrinology and metabolism
ISSN: 1522-1555
Titre abrégé: Am J Physiol Endocrinol Metab
Pays: United States
ID NLM: 100901226
Informations de publication
Date de publication:
01 09 2019
01 09 2019
Historique:
pubmed:
17
7
2019
medline:
24
3
2020
entrez:
17
7
2019
Statut:
ppublish
Résumé
Endothelin-1 (ET-1) is a potent vasoconstrictor and proinflammatory peptide that is upregulated in obesity. Herein, we tested the hypothesis that ET-1 signaling promotes visceral adipose tissue (AT) inflammation and disrupts glucose homeostasis. We also tested if reduced ET-1 is a required mechanism by which exercise ameliorates AT inflammation and improves glycemic control in obesity. We found that
Identifiants
pubmed: 31310581
doi: 10.1152/ajpendo.00178.2019
pmc: PMC6766607
doi:
Substances chimiques
Endothelin-1
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
E548-E558Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL137769
Pays : United States
Organisme : NIGMS NIH HHS
ID : R25 GM056901
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL088105
Pays : United States
Organisme : NHLBI NIH HHS
ID : K01 HL125503
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK007563
Pays : United States
Organisme : Canadian Institutes of Health
Pays : International
Organisme : NHLBI NIH HHS
ID : R01 HL127071
Pays : United States
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