Evaluation of Serum Glucagon-Like Peptide 1 and Vitamin D Levels in Elderly Patients with Bone Fractures.
Bone
Elderly patients
Fracture
Glucagon-like peptide-1
Vitamin D
Journal
Medical principles and practice : international journal of the Kuwait University, Health Science Centre
ISSN: 1423-0151
Titre abrégé: Med Princ Pract
Pays: Switzerland
ID NLM: 8901334
Informations de publication
Date de publication:
2020
2020
Historique:
received:
13
02
2019
accepted:
03
07
2019
pubmed:
17
7
2019
medline:
13
5
2021
entrez:
17
7
2019
Statut:
ppublish
Résumé
To evaluate the correlation between levels of serum vitamin D and glucagon-like peptide-1 (GLP-1) in elderly patients with bone fractures. This study included 56 patients and 31 control subjects. The patients included were those aged ≥65 years who were admitted to our hospital with a diagnosis of bone fracture. The control group comprised age-matched, healthy individuals. Levels of serum vitamin D and GLP-1 were measured and compared between the 2 groups. Significant differences were noted between the groups in terms of serum levels of vitamin D (p < 0.001) and serum levels of GLP-1 (p < 0.001). A positive correlation was observed between serum levels of vitamin D and GLP-1. Serum levels of GLP-1 were found to be significantly lower in elderly patients with bone fracture compared to healthy adults. In addition, a significant correlation was found between decreased vitamin D and GLP-1 levels. These results may therefore demonstrate the protective effects of GLP-1 on bone structure and metabolism, similar to those of vitamin D.
Identifiants
pubmed: 31311025
pii: 000502132
doi: 10.1159/000502132
pmc: PMC7315181
doi:
Substances chimiques
Ketone Bodies
0
Vitamin D
1406-16-2
Glucagon-Like Peptide 1
89750-14-1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
219-224Informations de copyright
© 2019 The Author(s) Published by S. Karger AG, Basel.
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