Cancer Testis Antigens and Immunotherapy: Where Do We Stand in the Targeting of PRAME?
PRAME
adoptive T cell therapy
antibody
cancer testis antigen
cancer vaccine
immunotherapy
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
15 Jul 2019
15 Jul 2019
Historique:
received:
11
06
2019
revised:
04
07
2019
accepted:
10
07
2019
entrez:
18
7
2019
pubmed:
18
7
2019
medline:
18
7
2019
Statut:
epublish
Résumé
PRAME or PReferentially expressed Antigen in Melanoma is a testis-selective cancer testis antigen (CTA) with restricted expression in somatic tissues and re-expression in various cancers. It is one of the most widely studied CTAs and has been associated with the outcome and risk of metastasis. Although little is known about its pathophysiological function, PRAME has gained interest as a candidate target for immunotherapy. This review provides an update on our knowledge on PRAME expression and function in healthy and malignant cells and the current immunotherapeutic strategies targeting PRAME with their specific challenges and opportunities. We also highlight some of the features that position PRAME as a unique cancer testis antigen to target.
Identifiants
pubmed: 31311081
pii: cancers11070984
doi: 10.3390/cancers11070984
pmc: PMC6678383
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Qatar National Research Fund
ID : QRLP10-G-1803024
Organisme : Qatar Biomedical Research Institute (QBRI)
ID : VR80
Références
Eur J Immunol. 2000 Mar;30(3):803-9
pubmed: 10741395
J Exp Med. 2001 Jan 1;193(1):73-88
pubmed: 11136822
Br J Haematol. 2001 Mar;112(4):916-26
pubmed: 11298586
N Engl J Med. 2002 Jan 24;346(4):235-42
pubmed: 11807147
Cancer Genet Cytogenet. 2002 Mar;133(2):118-23
pubmed: 11943337
Int J Cancer. 2004 Feb 20;108(5):704-11
pubmed: 14696097
Clin Cancer Res. 2004 Jul 1;10(13):4307-13
pubmed: 15240516
Cancer Res. 2004 Dec 15;64(24):9167-71
pubmed: 15604288
Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6092-7
pubmed: 15833814
Nat Rev Cancer. 2005 Aug;5(8):615-25
pubmed: 16034368
Cell. 2005 Sep 23;122(6):835-47
pubmed: 16179254
Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2794-9
pubmed: 16477019
Cell. 2006 Mar 24;124(6):1155-68
pubmed: 16564010
Leuk Res. 2006 Nov;30(11):1333-9
pubmed: 16620968
Clin Cancer Res. 2006 May 15;12(10):3130-6
pubmed: 16707612
Blood. 2006 Dec 15;108(13):4109-17
pubmed: 16931630
Cancer Res. 2006 Nov 15;66(22):10639-42
pubmed: 17108098
Leuk Res. 2007 Nov;31(11):1521-8
pubmed: 17382387
Genes Chromosomes Cancer. 2007 Sep;46(9):796-804
pubmed: 17534929
Breast Cancer Res Treat. 2008 May;109(2):359-65
pubmed: 17624586
Blood. 2008 Jan 1;111(1):236-42
pubmed: 17875804
Clin Cancer Res. 2008 Jun 1;14(11):3283-90
pubmed: 18519754
Leukemia. 2008 Sep;22(9):1721-7
pubmed: 18548092
Ann Hematol. 2008 Oct;87(10):809-18
pubmed: 18587578
Br J Cancer. 2008 Aug 5;99(3):398-403
pubmed: 18648365
Haematologica. 2008 Dec;93(12):1797-805
pubmed: 18815192
Nucleic Acids Res. 2009 Jan;37(Database issue):D816-9
pubmed: 18838390
Lung Cancer. 2010 Feb;67(2):151-9
pubmed: 19473719
Blood. 2009 Oct 8;114(15):3299-308
pubmed: 19625708
Cell. 2010 Mar 19;140(6):883-99
pubmed: 20303878
Leuk Res. 2010 Dec;34(12):1647-55
pubmed: 20409582
Mol Cancer. 2010 Aug 27;9:226
pubmed: 20799951
Am J Hematol. 2011 Jan;86(1):31-7
pubmed: 21132730
Blood. 2011 Mar 24;117(12):3353-62
pubmed: 21278353
J Clin Oncol. 2011 Mar 1;29(7):917-24
pubmed: 21282551
Mol Oncol. 2011 Apr;5(2):164-82
pubmed: 21376678
Clin Cancer Res. 2011 Jul 1;17(13):4550-7
pubmed: 21498393
Cancer Immunol Immunother. 2011 Sep;60(9):1243-55
pubmed: 21553146
Int J Oncol. 2011 Sep;39(3):665-72
pubmed: 21687938
J Immunother. 2011 Sep;34(7):556-67
pubmed: 21760528
Clin Cancer Res. 2011 Sep 1;17(17):5615-25
pubmed: 21771875
EMBO J. 2011 Aug 05;30(18):3786-98
pubmed: 21822215
N Engl J Med. 2011 Oct 6;365(14):1273-83
pubmed: 21991949
Biochem Biophys Res Commun. 2012 Mar 23;419(4):801-8
pubmed: 22390931
PLoS One. 2012;7(8):e42822
pubmed: 22912744
Oral Oncol. 2013 Feb;49(2):144-51
pubmed: 22944049
Expert Rev Anticancer Ther. 2012 Sep;12(9):1191-204
pubmed: 23098119
PLoS One. 2013;8(2):e58052
pubmed: 23460923
Cancer Biol Med. 2012 Mar;9(1):73-6
pubmed: 23691459
PLoS One. 2013 Aug 05;8(8):e70522
pubmed: 23940586
Immunol Rev. 2014 Jan;257(1):56-71
pubmed: 24329789
Clin Lab. 2014;60(1):55-61
pubmed: 24600975
Cancer Immunol Res. 2014 Apr;2(4):371-9
pubmed: 24764584
Tumour Biol. 2014 Dec;35(12):11741-50
pubmed: 25417200
J Immunother. 2015 Oct;38(8):311-20
pubmed: 26325375
Oncotarget. 2015 Nov 3;6(34):35770-81
pubmed: 26452036
Curr Opin Immunol. 2016 Apr;39:44-51
pubmed: 26796069
Clin Cancer Res. 2016 Mar 1;22(5):1234-42
pubmed: 26933176
Science. 2016 Apr 8;352(6282):227-31
pubmed: 26966191
Lancet Oncol. 2016 Jun;17(6):822-835
pubmed: 27132212
J Pathol Clin Res. 2015 Mar 16;1(3):144-59
pubmed: 27499900
J Thorac Oncol. 2016 Dec;11(12):2208-2217
pubmed: 27544054
ESMO Open. 2016 Aug 8;1(4):e000068
pubmed: 27843625
Leuk Res. 2017 Jan;52:43-49
pubmed: 27875783
Hum Pathol. 2017 Mar;61:130-139
pubmed: 27993576
Drugs. 2017 Mar;77(3):237-245
pubmed: 28110394
Front Med (Lausanne). 2017 Mar 08;4:18
pubmed: 28337438
JAMA Ophthalmol. 2017 Jun 1;135(6):541-549
pubmed: 28448663
J Clin Invest. 2017 Jun 30;127(7):2705-2718
pubmed: 28628042
Clin Sarcoma Res. 2017 Jun 15;7:11
pubmed: 28630682
Cancer Lett. 2017 Sep 10;403:144-151
pubmed: 28634046
Leukemia. 2017 Oct;31(10):2254-2257
pubmed: 28745331
Lancet Oncol. 2017 Nov;18(11):1493-1501
pubmed: 28988646
Oncotarget. 2017 Jul 26;8(39):65917-65931
pubmed: 29029482
Nature. 2018 Jan 4;553(7686):91-95
pubmed: 29160310
Cancer Res. 2018 Jun 15;78(12):3337-3349
pubmed: 29615432
Front Oncol. 2018 Mar 28;8:86
pubmed: 29644214
Front Immunol. 2018 May 01;9:947
pubmed: 29770138
J Cancer. 2018 Apr 19;9(10):1773-1781
pubmed: 29805703
Oncoimmunology. 2018 Sep 11;7(12):e1507600
pubmed: 30524904
J Transl Med. 2019 Jan 3;17(1):9
pubmed: 30602372
Immunity. 1997 Feb;6(2):199-208
pubmed: 9047241
Mol Microbiol. 1998 Jan;27(1):171-86
pubmed: 9466265
Cancer Res. 1998 Sep 15;58(18):4090-5
pubmed: 9751617