Pediatric Age Groups and Approach to Studies.

Adolescent Age Distribution Age Factors Child Child, Preschool Clinical Trials as Topic / methods Drug Evaluation / methods Humans Infant Infant, Newborn Pharmacokinetics
developmental drug metabolism developmental renal function pediatric clinical trials pediatric pharmacology perinatal drug metabolism

Journal

Therapeutic innovation & regulatory science
ISSN: 2168-4804
Titre abrégé: Ther Innov Regul Sci
Pays: Switzerland
ID NLM: 101597411

Informations de publication

Date de publication:
09 2019
Historique:
pubmed: 18 7 2019
medline: 19 3 2020
entrez: 18 7 2019
Statut: ppublish

Résumé

Pediatric clinical trials are often requested according to specific age ranges. In the past and still today, these ages may correspond to developmental stages, such as newborn, infancy, childhood, and adolescence. Selection of ages for pediatric participation in medication studies should correspond to ages of rapid changes in pharmacokinetics and pharmacodynamics. Age-related changes in several enzymes involved in drug metabolism and glomerular filtration are described as examples of optimal ages for study of specific drugs according to their pathways of disposition.

Identifiants

DOI: 10.1177/2168479019856572 PMID: 31311309
pubmed: 31311309
doi: 10.1177/2168479019856572
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

584-589

Auteurs

Kathleen M Job (KM)

1 Division of Clinical Pharmacology, Department of Pediatrics, University of Utah, Salt Lake City, UT, USA.
ORCID: 0000-0003-0255-654X

Margaret Gamalo (M)

2 Global Statistical Sciences, Eli Lilly and Co, Indianapolis, IN, USA.
ORCID: 0000-0003-2428-3298

Robert M Ward (RM)

1 Division of Clinical Pharmacology, Department of Pediatrics, University of Utah, Salt Lake City, UT, USA.
ORCID: 0000-0003-2178-5719

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Pediatric Age Groups and Approach to Studies.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Démographie › Répartition par âge › Pediatric Age Groups and Approach to Studies.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Facteurs épidémiologiques › Facteurs âges › Pediatric Age Groups and Approach to Studies.
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Pediatric Age Groups and Approach to Studies.
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Enfant d'âge préscolaire › Pediatric Age Groups and Approach to Studies.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études cliniques comme sujet › Essais cliniques comme sujet › Pediatric Age Groups and Approach to Studies.
questionsmedicales.fr › Techniques d'investigation › Évaluation de médicament › Pediatric Age Groups and Approach to Studies.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Pediatric Age Groups and Approach to Studies.
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Pediatric Age Groups and Approach to Studies.
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › Pediatric Age Groups and Approach to Studies.
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Pediatric Age Groups and Approach to Studies.