Misfolded proinsulin impairs processing of precursor of insulin receptor and insulin signaling in β cells.
Animals
Cell Line
Diabetes Mellitus, Type 2
/ metabolism
Endoplasmic Reticulum
/ metabolism
HEK293 Cells
Humans
Insulin
/ metabolism
Insulin-Secreting Cells
/ metabolism
Male
Mice
Mice, Inbred C57BL
Proinsulin
/ metabolism
Protein Folding
Receptor, Insulin
/ metabolism
Signal Transduction
/ physiology
ER stress
MIDY
insulin resistance
pancreatic
proinsulin misfolding
β cells
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
pubmed:
18
7
2019
medline:
26
5
2020
entrez:
18
7
2019
Statut:
ppublish
Résumé
Insulin resistance in classic insulin-responsive tissues is a hallmark of type 2 diabetes (T2D). However, the pathologic significance of β-cell insulin resistance and the underlying mechanisms contributing to defective insulin signaling in β cells remain largely unknown. Emerging evidence indicates that proinsulin misfolding is not only the molecular basis of mutant
Identifiants
pubmed: 31311313
doi: 10.1096/fj.201900442R
pmc: PMC6766638
doi:
Substances chimiques
Insulin
0
Proinsulin
9035-68-1
Receptor, Insulin
EC 2.7.10.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
11338-11348Références
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