HIV, immune activation and salt-sensitive hypertension (HISH): a research proposal.


Journal

BMC research notes
ISSN: 1756-0500
Titre abrégé: BMC Res Notes
Pays: England
ID NLM: 101462768

Informations de publication

Date de publication:
16 Jul 2019
Historique:
received: 24 05 2019
accepted: 11 07 2019
entrez: 18 7 2019
pubmed: 18 7 2019
medline: 7 1 2020
Statut: epublish

Résumé

The objective of this study is to quantify and compare the effect of excess dietary salt on immune cell activation and blood pressure in HIV versus HIV negative individuals. Salt-sensitivity is associated with increased immune cell activation in animal studies. This concept has not been tested in people living with HIV. This study will therefore add more information in elucidating the interaction between HIV infection and/or anti-retroviral therapy (ART), immune-activation/inflammation and hypertension.

Identifiants

pubmed: 31311574
doi: 10.1186/s13104-019-4470-2
pii: 10.1186/s13104-019-4470-2
pmc: PMC6636142
doi:

Substances chimiques

Anti-Retroviral Agents 0
Sodium Chloride, Dietary 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

424

Subventions

Organisme : FIC NIH HHS
ID : D43 TW009744
Pays : United States
Organisme : NHLBI NIH HHS
ID : K01 HL130497
Pays : United States

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Auteurs

Sepiso K Masenga (SK)

School of Medicine and Health Sciences, Mulungushi University, Livingstone, Zambia. smasenga@mu.ac.zm.
Department of Biomedical Sciences, School of Health Sciences, University of Zambia, Lusaka, Zambia. smasenga@mu.ac.zm.
Vanderbilt Institute for Global Health, Nashville, TN, USA. smasenga@mu.ac.zm.

Benson M Hamooya (BM)

School of Medicine and Health Sciences, Mulungushi University, Livingstone, Zambia.
Department of Epidemiology and Biostatistics, School of Public Health, University of Zambia, Lusaka, Zambia.

Selestine Nzala (S)

Department of Medical Education Development, University of Zambia, Lusaka, Zambia.

Geoffrey Kwenda (G)

Department of Biomedical Sciences, School of Health Sciences, University of Zambia, Lusaka, Zambia.

Douglas C Heimburger (DC)

Vanderbilt Institute for Global Health, Nashville, TN, USA.

Wilbroad Mutale (W)

Department of Health Policy and Management, School of Public Health, University of Zambia, Lusaka, Zambia.

John R Koethe (JR)

Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, USA.

Annet Kirabo (A)

Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA.
Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.

Sody M Munsaka (SM)

Department of Biomedical Sciences, School of Health Sciences, University of Zambia, Lusaka, Zambia.

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Classifications MeSH