ATGL-1 mediates the effect of dietary restriction and the insulin/IGF-1 signaling pathway on longevity in C. elegans.
ATGL-1
C. elegans
DAF-16
DAF-2
Dietary restriction
Longevity
Journal
Molecular metabolism
ISSN: 2212-8778
Titre abrégé: Mol Metab
Pays: Germany
ID NLM: 101605730
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
20
05
2019
revised:
28
06
2019
accepted:
02
07
2019
pubmed:
18
7
2019
medline:
14
4
2020
entrez:
18
7
2019
Statut:
ppublish
Résumé
Animal lifespan is controlled through genetic pathways that are conserved from nematodes to humans. Lifespan-promoting conditions in nematodes include fasting and a reduction of insulin/IGF signaling. Here we aimed to investigate the input of the Caenorhabditis elegans homologue of the mammalian rate-limiting lipolytic enzyme Adipose Triglyceride Lipase, ATGL-1, in longevity control. We used a combination of genetic and biochemical approaches to determine the role of ATGL-1 in accumulation of triglycerides and regulation of longevity. We found that expression of ATGL is increased in the insulin receptor homologue mutant daf-2 in a FoxO/DAF-16-dependent manner. ATGL-1 is also up-regulated by fasting and in the eat-2 loss-of-function mutant strain. Overexpression of ATGL-1 increases basal and maximal oxygen consumption rate and extends lifespan in C. elegans. Reduction of ATGL-1 function suppresses longevity of the long-lived mutants eat-2 and daf-2. Our results demonstrate that ATGL is required for extended lifespan downstream of both dietary restriction and reduced insulin/IGF signaling.
Identifiants
pubmed: 31311719
pii: S2212-8778(19)30482-X
doi: 10.1016/j.molmet.2019.07.001
pmc: PMC6717769
pii:
doi:
Substances chimiques
Caenorhabditis elegans Proteins
0
Insulin
0
Insulin-Like Growth Factor I
67763-96-6
ATGL-1 protein, C elegans
EC 3.1.1.3
Lipase
EC 3.1.1.3
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
75-82Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001430
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK046200
Pays : United States
Organisme : NIH HHS
ID : P40 OD010440
Pays : United States
Organisme : NIDDK NIH HHS
ID : R56 DK052057
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK052057
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK107498
Pays : United States
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier GmbH.. All rights reserved.
Références
Nature. 2010 Mar 25;464(7288):504-12
pubmed: 20336132
J Biol Chem. 2006 Jan 6;281(1):491-500
pubmed: 16267052
Cell Metab. 2017 Nov 7;26(5):753-763.e7
pubmed: 28988821
Science. 2006 May 5;312(5774):734-7
pubmed: 16675698
Bioessays. 2018 Aug;40(8):e1800005
pubmed: 29901833
J Lipid Res. 2011 Sep;52(9):1693-701
pubmed: 21743036
Science. 2008 Nov 7;322(5903):957-60
pubmed: 18988854
J Biol Chem. 2004 Nov 19;279(47):48968-75
pubmed: 15364929
J Biol Chem. 2009 May 15;284(20):13296-300
pubmed: 19297333
Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4640-5
pubmed: 20176933
G3 (Bethesda). 2012 Nov;2(11):1415-25
pubmed: 23173093
Curr Opin Endocrinol Diabetes Obes. 2015 Oct;22(5):340-6
pubmed: 26241026
Cell Metab. 2010 Nov 3;12(5):533-44
pubmed: 21035763
Aging Cell. 2010 Oct;9(5):667-84
pubmed: 20701600
Oncogene. 2008 Apr 7;27(16):2276-88
pubmed: 18391970
J Cell Biol. 2018 Jan 2;217(1):93-106
pubmed: 29074705
FASEB J. 2008 Mar;22(3):807-18
pubmed: 17928362
Mol Cell Biol. 2014 Nov 15;34(22):4165-76
pubmed: 25202121
Biochim Biophys Acta. 2014 Oct;1841(10):1555-1560
pubmed: 25135341
Cell. 2019 Mar 21;177(1):200-220
pubmed: 30901541
Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13091-6
pubmed: 9789046
FASEB J. 2016 Nov;30(11):3822-3834
pubmed: 27485820
Nat Cell Biol. 2015 Mar;17(3):196-203
pubmed: 25720959
Cell Metab. 2017 Jan 10;25(1):57-71
pubmed: 28094012
Science. 2003 Jan 24;299(5606):572-4
pubmed: 12543978
Diabetes. 2010 Apr;59(4):775-81
pubmed: 20068142
Cell. 2017 Mar 9;168(6):960-976
pubmed: 28283069
J Biol Chem. 2012 Jul 20;287(30):25038-48
pubmed: 22685301
Nature. 2009 Jan 8;457(7226):210-4
pubmed: 19052547
Nature. 2013 Jan 17;493(7432):338-45
pubmed: 23325216
Nat Rev Mol Cell Biol. 2006 Feb;7(2):85-96
pubmed: 16493415
PLoS One. 2011;6(10):e26349
pubmed: 22039468
Oncogene. 2008 Apr 7;27(16):2320-36
pubmed: 18391974
Cell Metab. 2013 Dec 3;18(6):883-95
pubmed: 24268737
Genetics. 1974 May;77(1):71-94
pubmed: 4366476
Oncotarget. 2016 Aug 30;7(35):56147-56152
pubmed: 27528229
Diabetes. 2006 Jan;55(1):148-57
pubmed: 16380488
Genome Res. 2013 Oct;23(10):1749-62
pubmed: 23800452
EMBO Rep. 2006 Jan;7(1):106-13
pubmed: 16239926
J Biol Chem. 2009 Jul 3;284(27):18282-91
pubmed: 19433586
Nat Med. 2011 Aug 21;17(9):1076-85
pubmed: 21857651
Mol Cell Biol. 2013 Sep;33(18):3659-66
pubmed: 23858058
Cell Metab. 2005 May;1(5):323-30
pubmed: 16054079
Int J Obes (Lond). 2005 Mar;29 Suppl 1:S36-9
pubmed: 15711582
J Biol Chem. 2004 Nov 5;279(45):47066-75
pubmed: 15337759
Diabetes. 2015 Feb;64(2):418-26
pubmed: 25614670
Science. 2004 Nov 19;306(5700):1383-6
pubmed: 15550674
J Cell Biochem. 2008 Dec 15;105(6):1430-6
pubmed: 18980248
Dev Cell. 2019 Mar 11;48(5):685-696.e5
pubmed: 30713071