Immunomodulation and preeclampsia.

Female Humans Immunomodulation Placenta Placenta Growth Factor Pre-Eclampsia / immunology Pregnancy
Immune system Inflammation NK cell PLGF Preeclampsia VEGF

Journal

Best practice & research. Clinical obstetrics & gynaecology
ISSN: 1532-1932
Titre abrégé: Best Pract Res Clin Obstet Gynaecol
Pays: Netherlands
ID NLM: 101121582

Informations de publication

Date de publication:
Oct 2019
Historique:
received: 07 03 2019
revised: 10 04 2019
accepted: 17 06 2019
pubmed: 18 7 2019
medline: 18 2 2020
entrez: 18 7 2019
Statut: ppublish

Résumé

Preeclampsia (PE) is an enigmatic syndrome, still with unknown aetiology and multi-factorial pathogenesis. Our understanding of the role of the immune system in PE development has undergone a transformation over the years. From a model based on the alterations in cell-mediated immunity, research moved on to a vision centred on the alteration of the humoural immunity and on the systemic involvement of the inflammatory system. The first hypothesis was classically derived from the evidence that an adequate maternal immunological response is necessary in pregnancy to allow the survival of the foetus. An abnormal response of the maternal immune system against the placenta may be the first pathogenetic step of PE, followed by a systemic inflammatory reaction. Currently available treatments for PE are mainly preventative with aspirin. Treatment aims to modulate inflammation and the immune system before their changes become established.

Identifiants

DOI: 10.1016/j.bpobgyn.2019.06.005 PMID: 31311760
pubmed: 31311760
pii: S1521-6934(19)30084-7
doi: 10.1016/j.bpobgyn.2019.06.005
pii:
doi:

Substances chimiques

Placenta Growth Factor 144589-93-5

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

87-96

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Marianna Pina Rambaldi (MP)

Obstetrics and Gynecology Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy.

Eran Weiner (E)

Department of Obstetrics & Gynecology, the Edith Wolfson Medical Center, Holon, Israel, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Federico Mecacci (F)

Obstetrics and Gynecology Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy.

Jacob Bar (J)

Department of Obstetrics & Gynecology, the Edith Wolfson Medical Center, Holon, Israel, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Felice Petraglia (F)

Obstetrics and Gynecology Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy. Electronic address: felice.petraglia@unifi.it.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Immunomodulation and preeclampsia.
questionsmedicales.fr › Phénomènes du système immunitaire › Immunomodulation › Immunomodulation and preeclampsia.
questionsmedicales.fr › Structures de l'embryon › Placenta › Immunomodulation and preeclampsia.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de la grossesse › Facteur de croissance placentaire › Immunomodulation and preeclampsia.
questionsmedicales.fr › Maladies urogénitales › Maladies de l'appareil urogénital féminin et complications de la grossesse › Complications de la grossesse › Pré-éclampsie › Immunomodulation and preeclampsia.
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Immunomodulation and preeclampsia.