BCL-2 family protein BOK is a positive regulator of uridine metabolism in mammals.

Animals Apoptosis / drug effects Biomarkers, Tumor / metabolism Cell Proliferation / drug effects DNA Damage Drug Resistance, Neoplasm / drug effects Fluorouracil / pharmacology Mammals Mice Multienzyme Complexes / metabolism Orotate Phosphoribosyltransferase / metabolism Orotidine-5'-Phosphate Decarboxylase / metabolism Protein Binding / drug effects Protein Domains Proto-Oncogene Proteins c-bcl-2 / chemistry Tumor Suppressor Protein p53 / metabolism Uridine / metabolism
Bok UMPS apoptosis chemoresistance metabolism

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
30 07 2019
Historique:
pubmed: 18 7 2019
medline: 31 3 2020
entrez: 18 7 2019
Statut: ppublish

Résumé

BCL-2 family proteins regulate the mitochondrial apoptotic pathway. BOK, a multidomain BCL-2 family protein, is generally believed to be an adaptor protein similar to BAK and BAX, regulating the mitochondrial permeability transition during apoptosis. Here we report that BOK is a positive regulator of a key enzyme involved in uridine biosynthesis; namely, uridine monophosphate synthetase (UMPS). Our data suggest that BOK expression enhances UMPS activity, cell proliferation, and chemosensitivity. Genetic deletion of

Identifiants

DOI: 10.1073/pnas.1904523116 PMID: 31311867 PMC: PMC6681708
pubmed: 31311867
pii: 1904523116
doi: 10.1073/pnas.1904523116
pmc: PMC6681708
doi:

Substances chimiques

Biomarkers, Tumor 0
Bok protein, mouse 0
Multienzyme Complexes 0
Proto-Oncogene Proteins c-bcl-2 0
Tumor Suppressor Protein p53 0
uridine 5'-monophosphate synthase 74870-74-9
Orotate Phosphoribosyltransferase EC 2.4.2.10
Orotidine-5'-Phosphate Decarboxylase EC 4.1.1.23
Fluorouracil U3P01618RT
Uridine WHI7HQ7H85

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

15469-15474

Informations de copyright

Copyright © 2019 the Author(s). Published by PNAS.

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

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Auteurs

Rahul Srivastava (R)

Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, 3086 Melbourne, Australia.

Zhipeng Cao (Z)

Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, 3086 Melbourne, Australia.

Christina Nedeva (C)

Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, 3086 Melbourne, Australia.

Samara Naim (S)

Institute of Pharmacology, University of Bern, Inselspital, INFO-F-603, 3010 Bern, Switzerland.

Daniel Bachmann (D)

Institute of Pharmacology, University of Bern, Inselspital, INFO-F-603, 3010 Bern, Switzerland.

Tatiana Rabachini (T)

Institute of Pharmacology, University of Bern, Inselspital, INFO-F-603, 3010 Bern, Switzerland.

Lahiru Gangoda (L)

Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, 3086 Melbourne, Australia.
Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute for Medical Research, 3052 Melbourne, Australia.

Sanjay Shahi (S)

Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, 3086 Melbourne, Australia.

Jason Glab (J)

Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, 3086 Melbourne, Australia.

Joseph Menassa (J)

Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, 3086 Melbourne, Australia.

Laura Osellame (L)

Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, 3086 Melbourne, Australia.

Tao Nelson (T)

Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, 3086 Melbourne, Australia.

Yuniel Fernandez-Marrero (Y)

Institute of Pharmacology, University of Bern, Inselspital, INFO-F-603, 3010 Bern, Switzerland.

Fiona Brown (F)

Australian Center for Blood Diseases, Monash University, 3004 Melbourne, Australia.

Andrew Wei (A)

Australian Center for Blood Diseases, Monash University, 3004 Melbourne, Australia.

Francine Ke (F)

Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute for Medical Research, 3052 Melbourne, Australia.

Lorraine O'Reilly (L)

Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute for Medical Research, 3052 Melbourne, Australia.

Marcel Doerflinger (M)

Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute for Medical Research, 3052 Melbourne, Australia.

Cody Allison (C)

Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute for Medical Research, 3052 Melbourne, Australia.

Andrew Kueh (A)

Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute for Medical Research, 3052 Melbourne, Australia.

Rob Ramsay (R)

Gastrointestinal Cancer Program, Peter MacCallum Cancer Centre, 3052 Melbourne, Australia.
ORCID: 0000-0001-5003-0433

Brian J Smith (BJ)

Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, 3086 Melbourne, Australia.

Suresh Mathivanan (S)

Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, 3086 Melbourne, Australia.

Thomas Kaufmann (T)

Institute of Pharmacology, University of Bern, Inselspital, INFO-F-603, 3010 Bern, Switzerland; thomas.kaufmann@pki.unibe.ch H.puthalakath@latrobe.edu.au.

Hamsa Puthalakath (H)

Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, 3086 Melbourne, Australia; thomas.kaufmann@pki.unibe.ch H.puthalakath@latrobe.edu.au.
ORCID: 0000-0001-5178-1175

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › BCL-2 family protein BOK is a positive...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › BCL-2 family protein BOK is a positive...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › BCL-2 family protein BOK is a positive...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › BCL-2 family protein BOK is a positive...
questionsmedicales.fr › Phénomènes génétiques › Altération de l'ADN › BCL-2 family protein BOK is a positive...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance aux médicaments antinéoplasiques › BCL-2 family protein BOK is a positive...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Pyrimidinones › Uracile › Fluorouracil › BCL-2 family protein BOK is a positive...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › BCL-2 family protein BOK is a positive...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › BCL-2 family protein BOK is a positive...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Complexes multienzymatiques › BCL-2 family protein BOK is a positive...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Glycosyltransferase › Pentosyltransferases › Orotate phosphoribosyltransferase › BCL-2 family protein BOK is a positive...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Lyases › Carbon-carbon lyases › Carboxy-lyases › Orotine 5'-phosphate decarboxylase › BCL-2 family protein BOK is a positive...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › BCL-2 family protein BOK is a positive...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure tertiaire des protéines › Domaines protéiques › BCL-2 family protein BOK is a positive...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes c-bcl-2 › BCL-2 family protein BOK is a positive...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Phosphoprotéines › Protéine p53 suppresseur de tumeur › BCL-2 family protein BOK is a positive...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Ribonucléosides › Uridine › BCL-2 family protein BOK is a positive...