Oncogenic KIT mutations induce STAT3-dependent autophagy to support cell proliferation in acute myeloid leukemia.
Journal
Oncogenesis
ISSN: 2157-9024
Titre abrégé: Oncogenesis
Pays: United States
ID NLM: 101580004
Informations de publication
Date de publication:
16 Jul 2019
16 Jul 2019
Historique:
received:
12
05
2017
accepted:
31
05
2019
revised:
10
04
2019
entrez:
18
7
2019
pubmed:
18
7
2019
medline:
18
7
2019
Statut:
epublish
Résumé
Autophagy is associated with both survival and cell death in myeloid malignancies. Therefore, deciphering its role in different genetically defined subtypes of acute myeloid leukemia (AML) is critical. Activating mutations of the KIT receptor tyrosine kinase are frequently detected in core-binding factor AML and are associated with a greater risk of relapse. Herein, we report that basal autophagy was significantly increased by the KIT
Identifiants
pubmed: 31311917
doi: 10.1038/s41389-019-0148-9
pii: 10.1038/s41389-019-0148-9
pmc: PMC6635375
doi:
Types de publication
Journal Article
Langues
eng
Pagination
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