Chronic Cognitive Deficits and Associated Histopathology Following Closed-Head Concussive Injury in Rats.
cognition
concussion
neurobehavior
neurodegeneration
traumatic brain injury
Journal
Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899
Informations de publication
Date de publication:
2019
2019
Historique:
received:
14
09
2018
accepted:
14
06
2019
entrez:
18
7
2019
pubmed:
18
7
2019
medline:
18
7
2019
Statut:
epublish
Résumé
Close-head concussive injury, as one of the most common forms of traumatic brain injury (TBI), has been shown to induce cognitive deficits that are long lasting. A concussive impact model was previously established in our lab that produces clinically relevant signs of concussion and induced acute pathological changes in rats. To evaluate the long-term effects of repeated concussions in this model, we utilized a comprehensive Morris water maze (MWM) paradigm for cognitive assessments at 1 and 6 months following repeated concussive impacts in rats. As such, adult Sprague-Dawley rats received either anesthesia (sham) or repeated concussive impacts (4 consecutive impacts at 1 h interval). At 1 month post-injury, results of the spatial learning task showed that the average latencies to locate the hidden "escape" platform were significantly longer in the injured rats over the last 2 days of the MWM testing compared to sham controls (
Identifiants
pubmed: 31312174
doi: 10.3389/fneur.2019.00699
pmc: PMC6614177
doi:
Types de publication
Journal Article
Langues
eng
Pagination
699Références
Neuroimage. 2001 Nov;14(5):1004-12
pubmed: 11697932
NeuroRehabilitation. 2002;17(4):333-44
pubmed: 12547981
Acad Emerg Med. 2004 Aug;11(8):809-19
pubmed: 15289185
Neuroscience. 2006 Apr 28;139(1):251-61
pubmed: 16325345
Behav Brain Res. 2006 Jun 30;170(2):241-56
pubmed: 16569442
J Neurosci. 2006 Apr 19;26(16):4236-46
pubmed: 16624944
J Neurotrauma. 1991 Winter;8(4):259-69
pubmed: 1803034
J Neurotrauma. 2008 Feb;25(2):153-71
pubmed: 18260798
Neuroscience. 2009 Mar 17;159(2):483-91
pubmed: 19167462
J Neurotrauma. 2010 Oct;27(10):1911-23
pubmed: 20684676
Dev Neurosci. 2010;32(5-6):510-8
pubmed: 20829578
J Neuropathol Exp Neurol. 2011 Jul;70(7):551-67
pubmed: 21666502
J Neurotrauma. 2012 Jan 20;29(2):281-94
pubmed: 21933013
Brain Inj. 2012;26(2):151-65
pubmed: 22360521
J Int Neuropsychol Soc. 2013 Jan;19(1):22-33
pubmed: 23058235
J Neurotrauma. 2013 May 1;30(9):688-701
pubmed: 23286417
Brain. 2013 Jan;136(Pt 1):28-42
pubmed: 23365092
Front Hum Neurosci. 2013 Feb 12;7:30
pubmed: 23408228
J Cogn Neurosci. 1992 Summer;4(3):281-8
pubmed: 23964884
Arch Phys Med Rehabil. 2014 Mar;95(3 Suppl):S152-73
pubmed: 24581903
Ann Biomed Eng. 2014 Aug;42(8):1618-30
pubmed: 24756867
Chiropr Man Therap. 2014 Nov 04;22(1):38
pubmed: 25379171
Behav Sci (Basel). 2015 Jan 30;5(1):43-58
pubmed: 25646994
Mol Cell Neurosci. 2015 May;66(Pt B):75-80
pubmed: 25748121
J Neurol. 2016 Jul;263(7):1332-41
pubmed: 27142715
Methods Mol Biol. 2016;1462:539-51
pubmed: 27604737
eNeuro. 2016 Oct 31;3(5):
pubmed: 27822499
Neurochem Int. 2017 Dec;111:103-107
pubmed: 28163060
J Head Trauma Rehabil. 2019 Jan/Feb;34(1):36-44
pubmed: 29863617
ASN Neuro. 2018 Jan-Dec;10:1759091418781921
pubmed: 29932344
J Neurosci Methods. 1984 May;11(1):47-60
pubmed: 6471907
Nature. 1982 Jun 24;297(5868):681-3
pubmed: 7088155
J Neurotrauma. 1994 Aug;11(4):417-31
pubmed: 7837282
J Neurosci. 1993 Sep;13(9):3916-25
pubmed: 8366351
J Neurotrauma. 1996 Jun;13(6):317-23
pubmed: 8835799
J Neurotrauma. 1998 Mar;15(3):199-216
pubmed: 9528920