Brain-based ranking of cognitive domains to predict schizophrenia.


Journal

Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065

Informations de publication

Date de publication:
15 10 2019
Historique:
received: 15 02 2019
revised: 10 06 2019
accepted: 26 06 2019
pubmed: 18 7 2019
medline: 21 4 2020
entrez: 18 7 2019
Statut: ppublish

Résumé

Schizophrenia is a devastating brain disorder that disturbs sensory perception, motor action, and abstract thought. Its clinical phenotype implies dysfunction of various mental domains, which has motivated a series of theories regarding the underlying pathophysiology. Aiming at a predictive benchmark of a catalog of cognitive functions, we developed a data-driven machine-learning strategy and provide a proof of principle in a multisite clinical dataset (n = 324). Existing neuroscientific knowledge on diverse cognitive domains was first condensed into neurotopographical maps. We then examined how the ensuing meta-analytic cognitive priors can distinguish patients and controls using brain morphology and intrinsic functional connectivity. Some affected cognitive domains supported well-studied directions of research on auditory evaluation and social cognition. However, rarely suspected cognitive domains also emerged as disease relevant, including self-oriented processing of bodily sensations in gustation and pain. Such algorithmic charting of the cognitive landscape can be used to make targeted recommendations for future mental health research.

Identifiants

pubmed: 31313451
doi: 10.1002/hbm.24716
pmc: PMC6865423
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4487-4507

Subventions

Organisme : Deutsche Forschungsgemeinschaft
ID : BZ2/2-1
Pays : International
Organisme : Deutsche Forschungsgemeinschaft
ID : BZ2/3-1
Pays : International
Organisme : Deutsche Forschungsgemeinschaft
ID : BZ2/4-1
Pays : International
Organisme : Paul Allen Foundation
Pays : International
Organisme : John D. and Catherine T. MacArthur Foundation
Pays : International
Organisme : Alfred P. Sloan Foundation
Pays : International
Organisme : ISI Foundation
Pays : International
Organisme : Exploratory Research Space
ID : OPSF449
Pays : International
Organisme : START-Program of the Faculty of Medicine
ID : 126/16
Pays : International
Organisme : Amazon AWS Research Grant
Pays : International
Organisme : International Research Training Group
ID : IRTG2150
Pays : International

Informations de copyright

© 2019 Wiley Periodicals, Inc.

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Auteurs

Teresa M Karrer (TM)

Department of Psychiatry, Psychotherapy and Psychosomatics, Faculty of Medicine, RWTH Aachen, Aachen, Germany.

Danielle S Bassett (DS)

Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania.
Department of Electrical and Systems Engineering, University of Pennsylvania, Philadelphia, Pennsylvania.
Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania.

Birgit Derntl (B)

Translational Brain Medicine, Jülich Aachen Research Alliance (JARA), Aachen, Germany.
Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.

Oliver Gruber (O)

Department of Psychiatry, University of Heidelberg, Heidelberg, Germany.

André Aleman (A)

BCN Neuroimaging Center, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Renaud Jardri (R)

Division of Psychiatry, University of Lille, CNRS UMR 9193, SCALab and CHU Lille, Fontan Hospital, Lille, France.

Angela R Laird (AR)

Department of Physics, Florida International University, Miami, Florida.

Peter T Fox (PT)

Research Imaging Institute, University of Texas Health Science Center, San Antonio, Texas.
South Texas Veterans Health Care System, San Antonio, Texas.
State Key Laboratory for Brain and Cognitive Sciences, University of Hong Kong, Hong Kong, China.

Simon B Eickhoff (SB)

Institute of Systems Neuroscience, Heinrich-Heine University, Düsseldorf, Germany.
Institute of Neuroscience and Medicine (INM-7), Research Centre Jülich, Jülich, Germany.

Olivier Grisel (O)

Parietal Team, INRIA Saclay/NeuroSpin, Palaiseau, France.

Gaël Varoquaux (G)

Parietal Team, INRIA Saclay/NeuroSpin, Palaiseau, France.

Bertrand Thirion (B)

Parietal Team, INRIA Saclay/NeuroSpin, Palaiseau, France.

Danilo Bzdok (D)

Department of Psychiatry, Psychotherapy and Psychosomatics, Faculty of Medicine, RWTH Aachen, Aachen, Germany.
Translational Brain Medicine, Jülich Aachen Research Alliance (JARA), Aachen, Germany.
Parietal Team, INRIA Saclay/NeuroSpin, Palaiseau, France.

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