Biogenesis of lysosome-related organelles complex-1 (BORC) regulates late endosomal/lysosomal size through PIKfyve-dependent phosphatidylinositol-3,5-bisphosphate.
AMP-Activated Protein Kinase Kinases
Animals
Autophagy
Endosomes
/ metabolism
HEK293 Cells
HeLa Cells
Humans
Lysosomal-Associated Membrane Protein 1
/ metabolism
Lysosomal Membrane Proteins
/ genetics
Lysosomes
/ metabolism
MAP Kinase Signaling System
Mice
Phosphatidylinositol 3-Kinases
/ genetics
Phosphatidylinositol Phosphates
/ metabolism
Protein Kinases
/ metabolism
Proteins
/ genetics
AMP-activated protein kinase (AMPK)
BORC
LAMTOR
PIKfyve
late endosome
lysosomal reformation
organelle size
phosphatidylinositol-3,5-bisphosphate [PI(3,5)P2]
Journal
Traffic (Copenhagen, Denmark)
ISSN: 1600-0854
Titre abrégé: Traffic
Pays: England
ID NLM: 100939340
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
15
07
2019
accepted:
15
07
2019
pubmed:
18
7
2019
medline:
16
7
2020
entrez:
18
7
2019
Statut:
ppublish
Résumé
Mechanisms that control lysosomal function are essential for cellular homeostasis. Lysosomes adapt in size and number to cellular needs but little is known about the underlying molecular mechanism. We demonstrate that the late endosomal/lysosomal multimeric BLOC-1-related complex (BORC) regulates the size of these organelles via PIKfyve-dependent phosphatidylinositol-3,5-bisphosphate [PI(3,5)P
Identifiants
pubmed: 31314175
doi: 10.1111/tra.12679
pmc: PMC6771566
doi:
Substances chimiques
Borcs7 protein, mouse
0
LAMTOR2 protein, mouse
0
Lysosomal-Associated Membrane Protein 1
0
Lysosomal Membrane Proteins
0
Phosphatidylinositol Phosphates
0
Proteins
0
Protein Kinases
EC 2.7.-
Pikfyve protein, mouse
EC 2.7.1.137
AMP-Activated Protein Kinase Kinases
EC 2.7.11.3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
674-696Informations de copyright
© 2019 The Authors. Traffic published by John Wiley & Sons Ltd.
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