Gata6
Animals
Cell Movement
Cells, Cultured
Fibrosis
/ prevention & control
GATA6 Transcription Factor
/ metabolism
Heart
/ physiology
Humans
Macrophages
/ immunology
Mice
Mice, Inbred C57BL
Mice, Transgenic
Myocardial Infarction
/ immunology
Myocardium
/ pathology
Pericardium
/ immunology
Ventricular Remodeling
Pericardial macrophage
fibrosis
myocardial infarction
Journal
Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918
Informations de publication
Date de publication:
16 07 2019
16 07 2019
Historique:
received:
23
07
2018
revised:
29
03
2019
accepted:
13
06
2019
entrez:
18
7
2019
pubmed:
18
7
2019
medline:
18
12
2019
Statut:
ppublish
Résumé
Macrophages play an important role in structural cardiac remodeling and the transition to heart failure following myocardial infarction (MI). Previous research has focused on the impact of blood-derived monocytes on cardiac repair. Here we examined the contribution of resident cavity macrophages located in the pericardial space adjacent to the site of injury. We found that disruption of the pericardial cavity accelerated maladaptive post-MI cardiac remodeling. Gata6
Identifiants
pubmed: 31315031
pii: S1074-7613(19)30280-8
doi: 10.1016/j.immuni.2019.06.010
pmc: PMC7574643
mid: NIHMS1628627
pii:
doi:
Substances chimiques
GATA6 Transcription Factor
0
Gata6 protein, mouse
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
131-140.e5Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK084391
Pays : United States
Organisme : CIHR
Pays : Canada
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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