Omega-3 Fatty Acids Survey in Men under Active Surveillance for Prostate Cancer: from Intake to Prostate Tissue Level.
Active surveillance
Eicosapentaenoic acid
Gleason score
High-grade prostate cancer
Omega-3 fatty acids
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
16 Jul 2019
16 Jul 2019
Historique:
received:
15
06
2019
revised:
12
07
2019
accepted:
12
07
2019
entrez:
19
7
2019
pubmed:
19
7
2019
medline:
10
1
2020
Statut:
epublish
Résumé
Dietary omega-3 fatty acids (ω3), particularly long-chain ω3 (LCω3), have protective effects against prostate cancer (PCa) in experimental studies. Observational studies are conflicting, possibly because of the biomarker used. This study aimed at evaluating associations between grade reclassification and ω3 levels assessed in prostatic tissue, red blood cells (RBC), and diet. We conducted a validation cross-sectional study nested within a phase II clinical trial. We identified 157 men diagnosed with low-risk PCa who underwent a first active surveillance repeat prostate biopsy session. Fatty acid (FA) intake was assessed using a food frequency questionnaire and their levels measured in prostate tissue and RBC. Associations were evaluated using logistic regression. At first repeat biopsy session, 39 (25%) men had high-grade PCa (grade group ≥2). We found that high LCω3-eicosapentaenoic acid (EPA) level in prostate tissue (odds ratio (OR) 0.25; 95% (confidence interval (CI) 0.08-0.79;
Identifiants
pubmed: 31315273
pii: nu11071616
doi: 10.3390/nu11071616
pmc: PMC6683032
pii:
doi:
Substances chimiques
Biomarkers
0
Fatty Acids, Omega-3
0
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
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