Adverse childhood experiences (ACEs) and cardiovascular development from childhood to early adulthood: study protocol of the Niagara Longitudinal Heart Study.
Adverse Childhood Experiences
Baroreflex
Biomarkers
/ blood
Blood Pressure
Cardiovascular Diseases
/ epidemiology
Carotid Artery, Common
/ diagnostic imaging
Carotid Intima-Media Thickness
Heart Rate
Heart Ventricles
/ diagnostic imaging
Humans
Longitudinal Studies
Research Design
Surveys and Questionnaires
Ultrasonography
Vascular Stiffness
cardiology
community child health
echocardiography
immunology
mental health
social medicine
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
16 07 2019
16 07 2019
Historique:
entrez:
19
7
2019
pubmed:
19
7
2019
medline:
6
8
2020
Statut:
epublish
Résumé
Recent reviews have found substantial links between a toxic childhood environment including child abuse and severe household dysfunction and adult cardiovascular disease (CVD). Collectively referred to as adverse childhood experiences (ACEs), this toxic environment is prevalent among children, with recent Canadian estimates of child abuse at 27%-32%, and severe household dysfunction at 49%. Based on these prevalence rates, the potential effect of ACEs on CVD is more significant than previously thought. Yet, how ACEs amplify the risk for later CVD remains unclear. Lifestyle risk factors only partially account for this connection, instead directing attention to the interaction between psychosocial factors and physiological mechanisms such as inflammation. The Niagara Longitudinal Heart Study (NLHS) examines how ACEs influence cardiovascular health (CVH) from childhood to early adulthood. Integrating the stress process and biological embedding models, this study examines how psychosocial and physiological factors in addition to lifestyle factors explain the relationship between ACEs and CVH. This follow-up study combines three baseline studies from 2007 to 2012 that collected CVH measures including child blood pressure, heart rate, left ventricular structure and function, arterial stiffness indices and baroreflex sensitivity on 564 children. Baseline data also include anthropometric, biological, lifestyle, behavioural, and psychosocial measures that varied across primary studies. Now over 18 years of age, we will recruit and retest as many participants from the baseline studies as possible collecting data on ACEs, CVH, anthropometric, lifestyle and psychosocial measures as well as blood, saliva and hair for physiological biostress markers. Ethics approval has been received for the NLHS follow-up. Written consent to participate in the follow-up study is obtained from each participant. Results testing all proposed hypotheses will be submitted for publication in peer-reviewed journals.
Identifiants
pubmed: 31315878
pii: bmjopen-2019-030339
doi: 10.1136/bmjopen-2019-030339
pmc: PMC6661634
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e030339Subventions
Organisme : CIHR
ID : 363774
Pays : Canada
Organisme : CIHR
ID : 399332
Pays : Canada
Organisme : CIHR
ID : 66959
Pays : Canada
Organisme : CIHR
ID : 199944
Pays : Canada
Informations de copyright
© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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