A Double-Blind Randomized Controlled Trial to Determine the Preventive Effect of Hangekobokuto on Aspiration Pneumonia in Patients Undergoing Cardiovascular Surgery.
Aged
Aged, 80 and over
Cardiovascular Surgical Procedures
/ adverse effects
Deglutition
/ drug effects
Deglutition Disorders
/ diagnosis
Double-Blind Method
Female
Humans
Male
Medicine, Kampo
Middle Aged
Plant Extracts
/ adverse effects
Pneumonia, Aspiration
/ diagnosis
Risk Factors
Time Factors
Tokyo
Treatment Outcome
Kampo medicine
aspiration pneumonia
dysphagia
hangekobokuto
Journal
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
ISSN: 2186-1005
Titre abrégé: Ann Thorac Cardiovasc Surg
Pays: Japan
ID NLM: 9703158
Informations de publication
Date de publication:
20 Dec 2019
20 Dec 2019
Historique:
pubmed:
19
7
2019
medline:
26
3
2020
entrez:
19
7
2019
Statut:
ppublish
Résumé
This study aimed to assess whether hangekobokuto (HKT) can prevent aspiration pneumonia in patients undergoing cardiovascular surgery. We performed a single-center, double-blinded, randomized, placebo-controlled study of HKT in patients undergoing cardiovascular surgery. JPS HKT extract granule (JPS-16) was used as HKT. The primary endpoint was defined as the prevention of postoperative aspiration pneumonia. The secondary endpoints included complete recovery from swallowing and coughing disorders. Between August 2014 and August 2015, a total of 34 patients were registered in this study. The rate of subjects with postoperative aspiration pneumonia was significantly lower in the HKT group than in the placebo group (p = 0.017). In high-risk patients for aspiration pneumonia, the rate was significantly lower in the HKT group than in the placebo group (p = 0.015). The rate of subjects with swallowing disorders tended to be lower in the HKT group than in the placebo group (p = 0.091), and in high-risk patients, the rate was significantly lower in the HKT group than in the placebo group (p = 0.038). HKT can prevent aspiration pneumonia in patients undergoing cardiovascular surgery. In high-risk patients for aspiration pneumonia, HKT can prevent aspiration pneumonia and improve swallowing disorders.
Identifiants
pubmed: 31316037
doi: 10.5761/atcs.oa.19-00128
pmc: PMC6923725
doi:
Substances chimiques
Plant Extracts
0
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
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