The longevity-promoting factor, TCER-1, widely represses stress resistance and innate immunity.
Aging
/ genetics
Animals
Caenorhabditis elegans
/ physiology
Caenorhabditis elegans Proteins
/ genetics
Disease Susceptibility
/ immunology
Fertility
/ genetics
Gene Expression Regulation
/ physiology
Immunity, Innate
/ genetics
Longevity
/ genetics
Mitogen-Activated Protein Kinases
/ genetics
Models, Animal
Mutation
Peptide Elongation Factors
/ genetics
Stress, Physiological
/ genetics
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
17 07 2019
17 07 2019
Historique:
received:
25
07
2018
accepted:
29
05
2019
entrez:
19
7
2019
pubmed:
19
7
2019
medline:
28
10
2019
Statut:
epublish
Résumé
Stress resistance and longevity are positively correlated but emerging evidence indicates that they are physiologically distinct. Identifying factors with distinctive roles in these processes is challenging because pro-longevity genes often enhance stress resistance. We demonstrate that TCER-1, the Caenorhabditis elegans homolog of human transcription elongation and splicing factor, TCERG1, has opposite effects on lifespan and stress resistance. We previously showed that tcer-1 promotes longevity in germline-less C. elegans and reproductive fitness in wild-type animals. Surprisingly, tcer-1 mutants exhibit exceptional resistance against multiple stressors, including infection by human opportunistic pathogens, whereas, TCER-1 overexpression confers immuno-susceptibility. TCER-1 inhibits immunity only during fertile stages of life. Elevating its levels ameliorates the fertility loss caused by infection, suggesting that TCER-1 represses immunity to augment fecundity. TCER-1 acts through repression of PMK-1 as well as PMK-1-independent factors critical for innate immunity. Our data establish key roles for TCER-1 in coordinating immunity, longevity and fertility, and reveal mechanisms that distinguish length of life from functional aspects of aging.
Identifiants
pubmed: 31316054
doi: 10.1038/s41467-019-10759-z
pii: 10.1038/s41467-019-10759-z
pmc: PMC6637209
doi:
Substances chimiques
Caenorhabditis elegans Proteins
0
Peptide Elongation Factors
0
Mitogen-Activated Protein Kinases
EC 2.7.11.24
Pmk-1 protein, C elegans
EC 2.7.11.24
TCER-1 protein, C elegans
EC 3.6.1.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3042Subventions
Organisme : NIA NIH HHS
ID : R01 AG051659
Pays : United States
Organisme : U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging)
ID : R01AG051659
Pays : International
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