Functional and morphological analysis of different aminoglycoside treatment regimens inducing hearing loss in mice.

ABR DPOAE auditory function cochelotoxicity furosemide gentamicin hair cells kanamycin mouse ototoxicity

Journal

Experimental and therapeutic medicine
ISSN: 1792-0981
Titre abrégé: Exp Ther Med
Pays: Greece
ID NLM: 101531947

Informations de publication

Date de publication:
Aug 2019
Historique:
received: 04 12 2018
accepted: 23 05 2019
entrez: 19 7 2019
pubmed: 19 7 2019
medline: 19 7 2019
Statut: ppublish

Résumé

Aminoglycoside ototoxicity is common in clinical practice but reliable protective agents currently do not exist. Aminoglycoside regimens causing ototoxicity in different laboratory animals are under investigation. The assessment method used most commonly to determine auditory effects is the auditory brainstem response (ABR). Distortion product otoacoustic emissions (DPOAE) have been used less frequently. A precise recommendation on the specific method to assess peripheral auditory function before and after aminoglycoside toxicity in mice does not exist. In order to evaluate various mouse models for ototoxic injury caused by various aminoglycoside regimens, there is a need for performing preliminary tests in small cohorts before large experiments. The aim of our study was to investigate different aminoglycoside regimens that cause substantial ototoxic damage

Identifiants

pubmed: 31316607
doi: 10.3892/etm.2019.7687
pii: ETM-0-0-7687
pmc: PMC6601143
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1123-1130

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Auteurs

Lukas Horvath (L)

Department of Otorhinolaryngology, Head and Neck Surgery, University of Zurich, University Hospital Zurich, 8091 Zurich, Switzerland.
Department of Biomedicine and The Clinic for Otorhinolaryngology, University Hospital Basel, 4031 Basel, Switzerland.

David Bächinger (D)

Department of Otorhinolaryngology, Head and Neck Surgery, University of Zurich, University Hospital Zurich, 8091 Zurich, Switzerland.

Tim Honegger (T)

Department of Otorhinolaryngology, Head and Neck Surgery, University of Zurich, University Hospital Zurich, 8091 Zurich, Switzerland.

Daniel Bodmer (D)

Department of Biomedicine and The Clinic for Otorhinolaryngology, University Hospital Basel, 4031 Basel, Switzerland.

Arianne Monge Naldi (AM)

Department of Otorhinolaryngology, Head and Neck Surgery, University of Zurich, University Hospital Zurich, 8091 Zurich, Switzerland.

Classifications MeSH