DNA Translocation through Hybrid Bilayer Nanopores.
Journal
The journal of physical chemistry. C, Nanomaterials and interfaces
ISSN: 1932-7447
Titre abrégé: J Phys Chem C Nanomater Interfaces
Pays: United States
ID NLM: 101299949
Informations de publication
Date de publication:
09 May 2019
09 May 2019
Historique:
entrez:
19
7
2019
pubmed:
19
7
2019
medline:
19
7
2019
Statut:
ppublish
Résumé
Pore functionalization has been explored by several groups as a strategy to control DNA translocation through solid-state nanopores. Here we present a hybrid nanopore system consisting of single-layer graphene and a DNA origami layer to achieve base-selective control of DNA translocation rate through aligned nanopores of the two layers. This is achieved by incorporating unpaired dangling bases called overhangs to the origami near the pore region. Molecular dynamics simulations were used to optimize the design of the origami nanopore and the overhangs. Specifically, we considered the influence of the number and spatial distribution of overhangs on translocation times. The simulations revealed that specific interactions between the overhangs and the translocating single-stranded DNA resulted in base-specific residence times.
Identifiants
pubmed: 31316684
doi: 10.1021/acs.jpcc.9b00399
pmc: PMC6636640
mid: NIHMS1038655
doi:
Types de publication
Journal Article
Langues
eng
Pagination
11908-11916Subventions
Organisme : NCI NIH HHS
ID : R35 CA210043
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
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