Vegetarian or gluten-free diets in patients with inflammatory bowel disease are associated with lower psychological well-being and a different gut microbiota, but no beneficial effects on the course of the disease.
Crohn's disease
gluten-free
inflammatory bowel disease
nutrition
ulcerative colitis
vegetarian
Journal
United European gastroenterology journal
ISSN: 2050-6406
Titre abrégé: United European Gastroenterol J
Pays: England
ID NLM: 101606807
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
18
01
2019
accepted:
07
03
2019
entrez:
19
7
2019
pubmed:
19
7
2019
medline:
19
7
2019
Statut:
ppublish
Résumé
Many inflammatory bowel disease (IBD) patients follow a restrictive diet due to perceived positive effects on their symptoms. We assessed the prevalence of vegetarian (VD) and gluten-free diets (GFDs) in IBD patients, the reasons for following such a diet, and whether nutrition has an impact on disease activity and microbiota composition. We included 1254 patients from the Swiss Inflammatory Bowel Disease Cohort Study with prospective acquisition of clinical data and psychosocial, disease-related and lifestyle factors between 2006 and 2015. Dietary habits were assessed through a self-report questionnaire. In 92 patients, we analysed intestinal mucosa-associated microbial composition using high-throughput sequencing. Overall, 4.1% ( Although we did not identify a relevant impact of a specific diet on the course of the disease, there was a significant association with lower psychological well-being in VD and GFD patients.
Sections du résumé
Background
Many inflammatory bowel disease (IBD) patients follow a restrictive diet due to perceived positive effects on their symptoms. We assessed the prevalence of vegetarian (VD) and gluten-free diets (GFDs) in IBD patients, the reasons for following such a diet, and whether nutrition has an impact on disease activity and microbiota composition.
Methods
We included 1254 patients from the Swiss Inflammatory Bowel Disease Cohort Study with prospective acquisition of clinical data and psychosocial, disease-related and lifestyle factors between 2006 and 2015. Dietary habits were assessed through a self-report questionnaire. In 92 patients, we analysed intestinal mucosa-associated microbial composition using high-throughput sequencing.
Results
Overall, 4.1% (
Conclusions
Although we did not identify a relevant impact of a specific diet on the course of the disease, there was a significant association with lower psychological well-being in VD and GFD patients.
Identifiants
pubmed: 31316781
doi: 10.1177/2050640619841249
pii: 10.1177_2050640619841249
pmc: PMC6620875
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
767-781Références
Am J Gastroenterol. 2010 Oct;105(10):2195-201
pubmed: 20461067
Gut. 2003 Feb;52(2):237-42
pubmed: 12524406
World J Gastroenterol. 2010 May 28;16(20):2484-95
pubmed: 20503448
BMC Microbiol. 2011 Jan 10;11:7
pubmed: 21219646
Nature. 2014 Jan 23;505(7484):559-63
pubmed: 24336217
J Crohns Colitis. 2017 Jul 1;11(7):769-784
pubmed: 28513805
Inflamm Bowel Dis. 2008 Mar;14(3):367-73
pubmed: 18092347
Science. 2011 Oct 7;334(6052):105-8
pubmed: 21885731
Ann Nutr Metab. 2009;54(4):253-7
pubmed: 19641302
Inflamm Bowel Dis. 2016 Jan;22(1):164-70
pubmed: 26383912
Gut. 2009 Dec;58(12):1606-11
pubmed: 19628674
Gastroenterology. 2012 Jan;142(1):46-54.e42; quiz e30
pubmed: 22001864
Int J Behav Nutr Phys Act. 2012 Jun 07;9:67
pubmed: 22676203
Gastroenterology. 2017 Feb;152(2):398-414.e6
pubmed: 27793606
Scand J Gastroenterol. 2013 Aug;48(8):921-5
pubmed: 23834276
Am J Gastroenterol. 2011 Apr;106(4):563-73
pubmed: 21468064
Clin Nutr. 2017 Apr;36(2):321-347
pubmed: 28131521
Psychol Med. 2012 Jan;42(1):15-28
pubmed: 21682948
J Crohns Colitis. 2017 Jan;11(1):3-25
pubmed: 27660341
Public Health Nutr. 2002 Aug;5(4):567-87
pubmed: 12186666
Nat Rev Gastroenterol Hepatol. 2015 Dec;12(12):720-7
pubmed: 26323879
JAMA Intern Med. 2016 Nov 1;176(11):1716-1717
pubmed: 27598396
Clin Gastroenterol Hepatol. 2014 Oct;12(10):1592-600
pubmed: 24107394
Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14691-6
pubmed: 20679230
Gut. 2018 Jan;67(1):108-119
pubmed: 27802154
Int J Epidemiol. 2009 Aug;38(4):922-31
pubmed: 18782896
Inflamm Bowel Dis. 2014 Apr;20(4):732-41
pubmed: 24562173
Gut. 2006 Aug;55(8):1207
pubmed: 16849351
Inflamm Bowel Dis. 2014 Jul;20(7):1194-7
pubmed: 24865778
Nat Med. 2019 Feb;25(2):323-336
pubmed: 30664783
Gut Microbes. 2010 May-Jun;1(3):135-7
pubmed: 21327021
Nat Rev Gastroenterol Hepatol. 2018 Sep;15(9):525-535
pubmed: 29789682
Gut. 2004 Oct;53(10):1479-84
pubmed: 15361498
Inflamm Bowel Dis. 2009 Jun;15(6):872-82
pubmed: 19235912