Trabecular Meshwork Regeneration - A Potential Treatment for Glaucoma.
glaucoma
intraocular pressure
regeneration
stem cells
trabecular meshwork
Journal
Current ophthalmology reports
ISSN: 2167-4868
Titre abrégé: Curr Ophthalmol Rep
Pays: United States
ID NLM: 101605578
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
entrez:
19
7
2019
pubmed:
19
7
2019
medline:
19
7
2019
Statut:
ppublish
Résumé
In this review, we overview the pathophysiology of primary open-angle glaucoma as it relates to the trabecular meshwork (TM), exploring modes of TM dysfunction and regeneration via stem cell therapies. Stem cells from a variety of sources, including trabecular meshwork, mesenchymal, adipose and induced pluripotent stem cells, have shown the potential to differentiate into TM cells Stem cell therapies for TM regeneration provide a robust and promising suite of treatments for eventual lowering of IOP and prevention of glaucomatous vision loss in humans in the future. Further investigation into stem cell homing mechanisms and the safety of introducing these cells into human anterior chamber, for instance, are required before clinical applications in treating glaucoma patients.
Identifiants
pubmed: 31316866
doi: 10.1007/s40135-019-00203-2
pmc: PMC6636338
mid: NIHMS1527154
doi:
Types de publication
Journal Article
Langues
eng
Pagination
80-88Subventions
Organisme : NEI NIH HHS
ID : P30 EY008098
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY025643
Pays : United States
Déclaration de conflit d'intérêts
Author Disclosure Statement Alexander Castro declares that he has no conflicts of interest. University of Pittsburgh owns a patent “trabecular meshwork stem cells” with Yiqin Du as one of the inventors.
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