The Natural Compound Climacostol as a Prodrug Strategy Based on pH Activation for Efficient Delivery of Cytotoxic Small Agents.
Wittig olefination
apoptosis
ciliated protists
cytotoxic compound
pH-activation
prodrug strategy
small natural agents
Journal
Frontiers in chemistry
ISSN: 2296-2646
Titre abrégé: Front Chem
Pays: Switzerland
ID NLM: 101627988
Informations de publication
Date de publication:
2019
2019
Historique:
received:
11
04
2019
accepted:
11
06
2019
entrez:
19
7
2019
pubmed:
19
7
2019
medline:
19
7
2019
Statut:
epublish
Résumé
We synthesized and characterized MOMO as a new small molecule analog of the cytotoxic natural product climacostol efficiently activated in mild extracellular acidosis. The synthesis of MOMO had a key step in the Wittig olefination for the construction of the carbon-carbon double bond in the alkenyl moiety of climacostol. The possibility of obtaining the target (
Identifiants
pubmed: 31316972
doi: 10.3389/fchem.2019.00463
pmc: PMC6609918
doi:
Types de publication
Journal Article
Langues
eng
Pagination
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