Fast screening and quantitative mass spectral imaging of thin-layer chromatography plates with flowing atmospheric-pressure afterglow high-resolution mass spectrometry.
Ambient desorption/ionization
Flowing atmospheric-pressure afterglow
Mass spectrometry
Quantification
Thin-layer chromatography
Journal
Analytical and bioanalytical chemistry
ISSN: 1618-2650
Titre abrégé: Anal Bioanal Chem
Pays: Germany
ID NLM: 101134327
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
22
05
2019
accepted:
01
07
2019
revised:
25
06
2019
pubmed:
19
7
2019
medline:
19
7
2019
entrez:
19
7
2019
Statut:
ppublish
Résumé
Thin-layer chromatography (TLC) was interfaced to high-resolution mass spectrometry (MS) using a flowing atmospheric-pressure afterglow (FAPA) ambient desorption/ionization source. The influence of different TLC stationary phases on the mass spectral signal response and mass spectral image quality in FAPA-MS was carefully investigated. Specifically, a mixture of selected analgesics (acetaminophen), alkaloids (nicotine and caffeine), and steroids (cortisone) was deposited on different stationary phases (silica plates, RP-modified silica plates, CN-modified silica plates, DIOL-modified silica plates, and NH
Identifiants
pubmed: 31317240
doi: 10.1007/s00216-019-02013-8
pii: 10.1007/s00216-019-02013-8
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM