Clonal evolution of chronic lymphocytic leukemia to Langerhans cell histiocytosis: a case report.
Chronic lymphocytic leukemia
Langerhans cell histiocytosis
TP53
Transdifferentiation
Journal
Virchows Archiv : an international journal of pathology
ISSN: 1432-2307
Titre abrégé: Virchows Arch
Pays: Germany
ID NLM: 9423843
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
08
03
2019
accepted:
11
06
2019
revised:
30
04
2019
pubmed:
19
7
2019
medline:
21
12
2019
entrez:
19
7
2019
Statut:
ppublish
Résumé
The traditional concept of unidirectional maturation of hematopoietic cells has been called into question due to the recognition of lineage plasticity, which is increasingly found also in the clonal evolution of hematopoietic and lymphoid malignancies. Here we present an unusual case of a patient with TP53-mutated chronic lymphocytic leukemia (CLL) treated with a PI3Kδ inhibitor evolving to clonally related Langerhans cell histiocytosis (LCH) with acquired BRAF V600E and STK11 mutations and loss of expression of PAX-5 and other examined B cell markers. In indolent B cell lymphoma, transformation to a more aggressive high-grade lymphoma occurs frequently during the course of disease and is thought to be caused by clonal evolution. Our case further supports the concept of significant lineage plasticity in lymphomas and raises the question of a potential role of novel pharmacologic agents in clonal evolution.
Identifiants
pubmed: 31317311
doi: 10.1007/s00428-019-02608-7
pii: 10.1007/s00428-019-02608-7
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
795-798Subventions
Organisme : TUEFF
ID : project 2320-0-0
Références
Lancet Oncol. 2004 Apr;5(4):248-50
pubmed: 15050956
Pathobiology. 2018;85(1-2):130-145
pubmed: 28719907
Mod Pathol. 2011 Nov;24(11):1421-32
pubmed: 21666687
Nature. 2017 Feb 23;542(7642):489-493
pubmed: 28199309
Am J Surg Pathol. 2013 Jul;37(7):978-86
pubmed: 23759932
Pathobiology. 2014;81(4):199-205
pubmed: 25228298
Virchows Arch. 2015 Oct;467(4):471-80
pubmed: 26286813
Blood. 2008 Jun 15;111(12):5433-9
pubmed: 18272816
J Hematop. 2009 May 09;2(3):135-41
pubmed: 19669194
N Am J Med Sci. 2013 Jun;5(6):386-91
pubmed: 23923114
Hematol Oncol Clin North Am. 2015 Oct;29(5):825-38
pubmed: 26461145
Leukemia. 2014 May;28(5):1052-9
pubmed: 24150215
Cell. 2013 Feb 14;152(4):714-26
pubmed: 23415222
Cancer Res. 2005 Dec 15;65(24):11297-303
pubmed: 16357136