The Crk adapter protein is essential for
Actins
/ metabolism
Adaptor Proteins, Signal Transducing
/ metabolism
Animals
Cell Differentiation
Cell Movement
Cytoskeleton
/ metabolism
Drosophila Proteins
/ metabolism
Drosophila melanogaster
/ embryology
Embryonic Development
/ genetics
Morphogenesis
Oncogene Protein v-crk
/ genetics
Proto-Oncogene Proteins c-crk
/ genetics
Signal Transduction
/ physiology
src Homology Domains
Journal
Molecular biology of the cell
ISSN: 1939-4586
Titre abrégé: Mol Biol Cell
Pays: United States
ID NLM: 9201390
Informations de publication
Date de publication:
15 08 2019
15 08 2019
Historique:
pubmed:
19
7
2019
medline:
12
5
2020
entrez:
19
7
2019
Statut:
ppublish
Résumé
Small Src homology domain 2 (SH2) and 3 (SH3) adapter proteins regulate cell fate and behavior by mediating interactions between cell surface receptors and downstream signaling effectors in many signal transduction pathways. The CT10 regulator of kinase (Crk) family has tissue-specific roles in phagocytosis, cell migration, and neuronal development and mediates oncogenic signaling in pathways like that of Abelson kinase. However, redundancy among the two mammalian family members and the position of the
Identifiants
pubmed: 31318326
doi: 10.1091/mbc.E19-05-0302
pmc: PMC6741062
doi:
Substances chimiques
Actins
0
Adaptor Proteins, Signal Transducing
0
Drosophila Proteins
0
Oncogene Protein v-crk
0
Proto-Oncogene Proteins c-crk
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2399-2421Subventions
Organisme : NIGMS NIH HHS
ID : F32 GM117803
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM118096
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009156
Pays : United States
Organisme : CIHR
ID : 156279
Pays : Canada
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