Endothelial Foxp1 Suppresses Atherosclerosis via Modulation of Nlrp3 Inflammasome Activation.

Animals Atherosclerosis / genetics Endothelial Cells / metabolism Forkhead Transcription Factors / genetics Human Umbilical Vein Endothelial Cells / metabolism Humans Inflammasomes / genetics Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic NLR Family, Pyrin Domain-Containing 3 Protein / genetics Repressor Proteins / genetics
atherosclerosis endothelium inflammasome mice simvastatin

Journal

Circulation research
ISSN: 1524-4571
Titre abrégé: Circ Res
Pays: United States
ID NLM: 0047103

Informations de publication

Date de publication:
30 08 2019
Historique:
pubmed: 19 7 2019
medline: 9 7 2020
entrez: 19 7 2019
Statut: ppublish

Résumé

Endothelial dysfunction results in sustained and chronic vascular inflammation, which is central to atherosclerotic diseases. However, transcriptional regulation of vascular endothelial inflammation has not been well clarified. This study aims to explore Foxp (forkhead box P) transcription factor 1 in regulation of endothelial homeostasis, atherogenesis, and its mechanisms. To assess the importance of Foxp1 in atherosclerosis, Foxp1 expression was analyzed in human coronary artery and mouse artery, and we observed significant downregulation of Foxp1 in atherosclerotic and atherosusceptible endothelium. Endothelial-specific Foxp1 knockout mice (Foxp1 These data are the first in vivo experimental validation of an atheroprotective role of endothelial Klf2 and Foxp1, which reveals a Klf2-Foxp1 transcriptional network in endothelial cells as a novel regulator of endothelial inflammasome activation for atherogenesis, therefore, provides opportunities for therapeutic intervention of atherosclerotic diseases and uncovers a novel atheroprotective mechanism for simvastatin.

Identifiants

DOI: 10.1161/CIRCRESAHA.118.314402 PMID: 31318658
pubmed: 31318658
doi: 10.1161/CIRCRESAHA.118.314402
doi:

Substances chimiques

Forkhead Transcription Factors 0
Foxp1 protein, mouse 0
Inflammasomes 0
NLR Family, Pyrin Domain-Containing 3 Protein 0
Nlrp3 protein, mouse 0
Repressor Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

590-605

Commentaires et corrections

Type : CommentIn
Type : CommentIn

Auteurs

Tao Zhuang (T)

From the Key Laboratory of Arrhythmias of the Ministry of Education of China, Research Center for Translational Medicine (T.Z., J.L., X.C., L.Z., H.S., Z.Y., Z.L., Y.Z.), Shanghai East Hospital, Tongji University School of Medicine, China.

Jie Liu (J)

From the Key Laboratory of Arrhythmias of the Ministry of Education of China, Research Center for Translational Medicine (T.Z., J.L., X.C., L.Z., H.S., Z.Y., Z.L., Y.Z.), Shanghai East Hospital, Tongji University School of Medicine, China.

Xiaoli Chen (X)

From the Key Laboratory of Arrhythmias of the Ministry of Education of China, Research Center for Translational Medicine (T.Z., J.L., X.C., L.Z., H.S., Z.Y., Z.L., Y.Z.), Shanghai East Hospital, Tongji University School of Medicine, China.

Lin Zhang (L)

From the Key Laboratory of Arrhythmias of the Ministry of Education of China, Research Center for Translational Medicine (T.Z., J.L., X.C., L.Z., H.S., Z.Y., Z.L., Y.Z.), Shanghai East Hospital, Tongji University School of Medicine, China.

Jingjiang Pi (J)

Cardiology (J.P., Q.Z.), Shanghai East Hospital, Tongji University School of Medicine, China.

Huimin Sun (H)

From the Key Laboratory of Arrhythmias of the Ministry of Education of China, Research Center for Translational Medicine (T.Z., J.L., X.C., L.Z., H.S., Z.Y., Z.L., Y.Z.), Shanghai East Hospital, Tongji University School of Medicine, China.

Li Li (L)

Cardiovascular Institute, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia (L.L.).

Robert Bauer (R)

Cardiology Division, Department of Medicine (R.B.), Columbia University, New York, NY.

Haikun Wang (H)

Key Laboratory of Molecular Virology and Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences, China (H.W.).

Zuoren Yu (Z)

From the Key Laboratory of Arrhythmias of the Ministry of Education of China, Research Center for Translational Medicine (T.Z., J.L., X.C., L.Z., H.S., Z.Y., Z.L., Y.Z.), Shanghai East Hospital, Tongji University School of Medicine, China.

Qi Zhang (Q)

Cardiology (J.P., Q.Z.), Shanghai East Hospital, Tongji University School of Medicine, China.

Brian Tomlinson (B)

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR (B.T.).

Paul Chan (P)

Division of Cardiology, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taiwan (P.C.).

Xiangjian Zheng (X)

Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University (X.Z.).
Laboratory of Cardiovascular Signaling, Centenary Institute, and Sydney Medical School, University of Sydney, Sydney, NSW, Australia (X.Z.).

Edward Morrisey (E)

Department of Cell and Developmental Biology (E.M.), University of Pennsylvania, Philadelphia.
Department of Medicine (E.M.), University of Pennsylvania, Philadelphia.
Penn Cardiovascular Institute (E.M.), University of Pennsylvania, Philadelphia.
Penn Institute for Regenerative Medicine (E.M.), University of Pennsylvania, Philadelphia.

Zhongmin Liu (Z)

From the Key Laboratory of Arrhythmias of the Ministry of Education of China, Research Center for Translational Medicine (T.Z., J.L., X.C., L.Z., H.S., Z.Y., Z.L., Y.Z.), Shanghai East Hospital, Tongji University School of Medicine, China.

Muredach Reilly (M)

Cardiology Division, Department of Medicine and the Irving Institute for Clinical and Translational Research (M.R.), Columbia University, New York, NY.

Yuzhen Zhang (Y)

From the Key Laboratory of Arrhythmias of the Ministry of Education of China, Research Center for Translational Medicine (T.Z., J.L., X.C., L.Z., H.S., Z.Y., Z.L., Y.Z.), Shanghai East Hospital, Tongji University School of Medicine, China.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Endothelial Foxp1 Suppresses Atherosclerosis...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Artériopathies oblitérantes › Artériosclérose › Athérosclérose › Endothelial Foxp1 Suppresses Atherosclerosis...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › Endothelial Foxp1 Suppresses Atherosclerosis...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif hélice ailée › Facteurs de transcription Forkhead › Endothelial Foxp1 Suppresses Atherosclerosis...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › Cellules endothéliales de la veine ombilicale humaine › Endothelial Foxp1 Suppresses Atherosclerosis...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Endothelial Foxp1 Suppresses Atherosclerosis...
questionsmedicales.fr › Structures macromoléculaires › Complexes multiprotéiques › Inflammasomes › Endothelial Foxp1 Suppresses Atherosclerosis...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Endothelial Foxp1 Suppresses Atherosclerosis...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Endothelial Foxp1 Suppresses Atherosclerosis...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Endothelial Foxp1 Suppresses Atherosclerosis...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Endothelial Foxp1 Suppresses Atherosclerosis...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Protéines NLR › Protéine-3 de la famille des NLR contenant un domaine pyrine › Endothelial Foxp1 Suppresses Atherosclerosis...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéines de répression › Endothelial Foxp1 Suppresses Atherosclerosis...